{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:46:33Z","timestamp":1771562793686,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Background:<\/i> The opportunistic yeast <i>Malassezia<\/i> is considered to be one of the factors that can contribute to atopic eczema (AE). Elevated serum IgE levels, T-cell proliferation and positive skin prick test (SPT) and atopy patch test (APT) reactions to <i>Malassezia<\/i> are found among AE patients. <i>Methods:<\/i> Sera from 127 AE patients, 14 patients with seborrheic dermatitis (SD) and 33 healthy controls were investigated for IgE and IgG4 to <i>M. sympodialis <\/i>extract and four recombinant <i>Malassezia<\/i> allergens; rMala s 1, rMala s 5, rMala s 6, and rMala s 9. In addition, IgG to the recombinant allergens was analyzed. The IgG and IgG4 levels were compared to IgE levels and in vivo reactions (SPT and APT) to <i>Malassezia<\/i>.<i> Results:<\/i> AE patients with serum IgE levels >0.35 kU\/l to <i>M. sympodialis<\/i> extract had significantly higher IgG4 levels to <i>M. sympodialis<\/i> extract than AE patients without detectable serum IgE to <i>M. sympodialis<\/i> extract, SD patients and healthy controls. Among the AE patients with and without detectable serum IgE to <i>M. sympodialis<\/i> extract, respectively, there were no differences in IgG4 levels between patients with positive or negative in vivo reactions to <i>M. sympodialis<\/i> extract. IgG4 to the rMala s allergens was almost exclusively found among patients with IgE to the same allergen. Within the four tested rMala s allergens, most IgG4 reactions were found to rMala s 6, an allergen with homology to cyclophilin. <i>Conclusions:<\/i> Elevated serum IgG4 to<i> M. sympodialis<\/i> extract accompanies elevated serum IgE to the extract. This is further confirmed by the association between IgG\/IgG4 and IgE to recombinant <i>Malassezia<\/i> allergens.<\/jats:p>","DOI":"10.1159\/000080651","type":"journal-article","created":{"date-parts":[[2004,9,8]],"date-time":"2004-09-08T08:46:05Z","timestamp":1094633165000},"page":"93-100","source":"Crossref","is-referenced-by-count":22,"title":["Elevated Levels of IgG and IgG4 to <i>Malassezia<\/i> Allergens in Atopic Eczema Patients with IgE Reactivity to<i> Malassezia<\/i>"],"prefix":"10.1159","volume":"135","author":[{"given":"Catharina","family":"Johansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tengvall Linder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob C.","family":"Aalberse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Scheynius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00115.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000053860"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1363-1367.2002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00097.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01758.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/000155500459303"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00181.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/13693780310001615367"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.126.5.627"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04168-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00126.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2003.11107810.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01807.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/000155501317208363"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:37:06Z","timestamp":1745465826000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080651","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}