{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:28Z","timestamp":1745554228387,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T00:00:00Z","timestamp":1100649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T00:00:00Z","timestamp":1100649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Renal osteodystrophy is one of the major complications in patients with chronic renal failure. Large C-PTH fragments are secreted from the parathyroid glands and exert antagonistic actions against PTH-(1\u201384). The PTH-(1\u201384)\/large C-PTH fragments ratio reflects both biosynthesis and processing of PTH; however the alteration of the ratio under vitamin D therapy has not been investigated. &lt;i&gt;Methods:&lt;\/i&gt; Seventeen hemodialysis patients with intact PTH levels of &gt;300 pg\/ml were enrolled. Calcitriol or maxacalcitol were administered intravenously for 78 weeks. Intact PTH, PTH-(1\u201384), and the PTH-(1\u201384)\/large C-PTH fragments ratio were measured at 0, 13, 26, 52 and 78 weeks. &lt;i&gt;Results:&lt;\/i&gt; Intact PTH and PTH-(1\u201384) levels, which were 492.0 \u00b1 115.7 and 303.4 \u00b1 105.4 pg\/ml, respectively, at baseline, significantly decreased at the end of the study to 268.9 \u00b1 121.9 (p &lt; 0.0001) and 190.7 \u00b1 106.9 pg\/ml (p = 0.0008), respectively. In contrast, large C-PTH fragments, which were 152.7 \u00b1 53.5 pg\/ml at baseline, did not significantly change at 78 weeks (144.5 \u00b1 72.2 pg\/ml, p = 0.7612). Consequently, the PTH-(1\u201384)\/large C-PTH fragments ratio was significantly reduced from 2.25 \u00b1 1.31 to 1.47 \u00b1 0.89 (p = 0.0004). &lt;i&gt;Conclusion:&lt;\/i&gt; The PTH-(1\u201384)\/large C-PTH fragments ratio reflects the change of PTH biosynthesis, processing and secretion from the parathyroid glands, and it may be a beneficial marker to evaluate the overall biological PTH action and predict bone turnover status in hemodialysis patients under intravenous vitamin D therapy.<\/jats:p>","DOI":"10.1159\/000080680","type":"journal-article","created":{"date-parts":[[2004,11,9]],"date-time":"2004-11-09T07:56:35Z","timestamp":1099986995000},"page":"c93-c100","source":"Crossref","is-referenced-by-count":2,"title":["Intravenous Vitamin D Therapy Reduces PTH-(1\u201384)\/Large C Fragments Ratio in Chronic Hemodialysis Patients"],"prefix":"10.1159","volume":"98","author":[{"given":"Takashi","family":"Kihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanori","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Kohmoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00222.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1993.64"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1994.342"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200801-009AW"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.214841"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.75.1.145"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F13.9.2294"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.00949.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.142.4.1386"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0272-6386%2895%2990599-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.140.8.3633"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1677%2Fjme.0.0150061"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M108576200"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2002.34519"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.143.1.171"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI111639"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:37:17Z","timestamp":1745465837000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,17]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080680","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2004,11,17]]}}}