{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:33Z","timestamp":1745554233537,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Introduction:<\/i> We previously developed a noninvasive video urodynamic study using color Doppler ultrasonography. We sought the best flow velocity-related parameter which would allow prediction of an improvement in lower urinary tract symptoms (LUTS) after \u03b1<sub>1<\/sub>-blocker treatment. <i>Methods:<\/i> Twenty-two men with benign prostatic hyperplasia who were treated with a nonselective \u03b1<sub>1<\/sub>-blocker (urapidil) were included. Subjective symptoms were evaluated using the International Prostate Symptom Score (IPSS) before and after \u03b1<sub>1<\/sub>-blocker treatment. We measured the flow velocities using a transperineal ultrasound technique in the distal prostatic urethra just proximal to the external urethral sphincter (V<sub>1<\/sub>) and in the sphincteric urethra (V<sub>2<\/sub>), and used them to obtain the velocity ratio (VR = V<sub>1<\/sub>\/V<sub>2<\/sub>). The corresponding functional cross-sectional areas of the urethra at these two sites (A<sub>1<\/sub> and A<sub>2<\/sub>) were calculated as Q<sub>max<\/sub>\/V. All these parameters obtained by the velocity-flow urodynamics were compared before treatment and after 4 weeks. <i>Results:<\/i> After treatment, V<sub>1<\/sub> and VR were decreased, and A<sub>1<\/sub> was increased. V<sub>2<\/sub> correlated best with the change in IPSS before and after \u03b1<sub>1<\/sub>-blocker therapy, with Spearman\u2019s rho of 0.584. All men with V<sub>2<\/sub> exceeding 50 cm\/s did not show an improvement in the LUTS. <i>Conclusions:<\/i> The maximum flow velocity at the sphincteric urethra (V<sub>2<\/sub>) can predict the subjective outcome of \u03b1<sub>1<\/sub>-blocker treatment. The velocity-flow parameters changed after \u03b1<sub>1<\/sub>-blocker treatment. We confirmed that the transperineal ultrasound urodynamic study is not only noninvasive but also informative.<\/jats:p>","DOI":"10.1159\/000080837","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T15:02:15Z","timestamp":1100271735000},"page":"252-257","source":"Crossref","is-referenced-by-count":2,"title":["Change in Parameters before and after Alpha-1-Blocker Therapy for Men with Lower Urinary Tract Symptoms Using Color Doppler Ultrasound Urodynamics: Possible Application for Prediction of Clinical Outcome"],"prefix":"10.1159","volume":"73","author":[{"given":"Yuichi","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nishiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Kumon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fpros.2990160309"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2899%2900340-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fpros.2990250107"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2896%2900040-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2894%2980120-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199505000-00047"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199605000-00032"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199811000-00051"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199811000-00052"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2800%2900684-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199606000-00057"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200101000-00010"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2800%2900804-9"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80837","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:39:16Z","timestamp":1745465956000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080837","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2004]]}}}