{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:21:11Z","timestamp":1770477671718,"version":"3.49.0"},"reference-count":8,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; A two-compound product containing calcipotriol 50 \u00b5g\/g and betamethasone dipropionate 0.5 mg\/g (Daivobet&lt;sup&gt;\u00ae&lt;\/sup&gt;, Dovobet&lt;sup&gt;\u00ae&lt;\/sup&gt;) has been demonstrated to be an effective, once daily, treatment for psoriasis vulgaris. &lt;i&gt;Objective:&lt;\/i&gt; To compare the efficacy and safety of treatment with the two-compound product for 4 weeks followed by calcipotriol for 4 weeks, with that of tacalcitol for 8 weeks in patients with stable psoriasis vulgaris. &lt;i&gt;Methods:&lt;\/i&gt; 501 patients were randomised to double-blind treatment with the two-compound product followed by calcipotriol 50 \u00b5g\/g once daily, or to tacalcitol 4 \u00b5g\/g once daily. &lt;i&gt;Results:&lt;\/i&gt; Treatment with the two-compound product\/calcipotriol was significantly more effective than tacalcitol in terms of mean percentage PASI reduction (65.0 vs. 33.3% at week 4 and 59.0 vs. 38.4% at week 8; p &lt; 0.001 for both). &lt;i&gt;Conclusion:&lt;\/i&gt; A treatment regimen comprising calcipotriol\/betamethasone ointment (Daivobet) for 4 weeks followed by calcipotriol for 4 weeks is superior to tacalcitol ointment for 8 weeks in patients with psoriasis vulgaris.<\/jats:p>","DOI":"10.1159\/000080854","type":"journal-article","created":{"date-parts":[[2004,11,9]],"date-time":"2004-11-09T07:56:35Z","timestamp":1099986995000},"page":"308-313","source":"Crossref","is-referenced-by-count":52,"title":["Efficacy of Treatment with Calcipotriol\/Betamethasone Dipropionate Followed by Calcipotriol Alone Compared with Tacalcitol for the Treatment of Psoriasis vulgaris: A Randomised, Double-Blind Trial"],"prefix":"10.1159","volume":"209","author":[{"given":"J.-P.","family":"Ortonne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lecha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Goodfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.2001.00832.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199503023320907"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.04967.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000066440"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2003.130"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080%2F00015550252948194"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000250839"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1998.02461.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:39:24Z","timestamp":1745465964000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2004,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080854","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}