{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:28:51Z","timestamp":1761560931484,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; To investigate the hypothesis that primary open-angle glaucoma (POAG) is associated with a common insertion-deletion (I\/D) polymorphism in the angiotensin-converting enzyme (ACE) gene. &lt;i&gt;Methods:&lt;\/i&gt; ACE I\/D polymorphism was investigated in a control group of healthy subjects (n = 101) and in a group of patients diagnosed with POAG (n = 104). Polymerase chain reaction detection of I\/D polymorphism was used to determine the presence of the two ACE alleles in the groups. &lt;i&gt;Results:&lt;\/i&gt; Neither the I\/D genotype distributions nor the allele frequencies differed significantly between POAG and control subjects (DD genotype 34.6 vs. 39.6%; ID genotype 53.9 vs. 40.6%; II genotype 11.5 vs. 19.8%, p = 0.1; D allele 61.5 vs. 60%; I allele 38.5 vs. 40%, p = 0.8). &lt;i&gt;Conclusion:&lt;\/i&gt; We could not identify a possible association of the I\/D polymorphism in the ACE gene with POAG, however further studies with larger patient numbers in different populations are required to clarify the role of ACE gene in susceptibility to POAG.<\/jats:p>","DOI":"10.1159\/000080946","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T12:13:58Z","timestamp":1102076038000},"page":"415-418","source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin-Converting Enzyme Insertion-Deletion Polymorphism in Primary Open-Angle Glaucoma"],"prefix":"10.1159","volume":"218","author":[{"given":"Mehtap","family":"Ozkur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"Erbagci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kivanc","family":"Gungor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muradiye","family":"Nacak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukru","family":"Aynacioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necdet A.","family":"Bekir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.85.24.9386"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114844"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2362.2001.00839.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1350-9462%2802%2900008-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.80.2.159"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.86.6.676"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.ph.54.030192.001303"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1006%2Fexer.2000.0866"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2896%2980398-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000063146.40351.AD"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:40:01Z","timestamp":1745466001000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2004,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080946","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"type":"print","value":"0030-3755"},{"type":"electronic","value":"1423-0267"}],"subject":[],"published":{"date-parts":[[2004]]}}}