{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:10:09Z","timestamp":1745467809408,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>To determine whether positron emission tomography (PET) can be used for imaging of neuroreceptors in eyes of rabbits. PET imaging of dopamine D&lt;sub&gt;2&lt;\/sub&gt; receptor, dopamine transporter, serotonin&lt;sub&gt;1A&lt;\/sub&gt; receptor and sigma&lt;sub&gt;1&lt;\/sub&gt; receptor in the eyes and brain was performed using corresponding positron-emitting ligands in baseline, pretreatment and displacement conditions. The 4 radioligands outlined the eyes and brain in the baseline. Pretreatment resulted in a slight reduction (26\u201328%) in the uptake in the anterior segments of eyes. The binding of each radioligand in the iris-ciliary body and retina was confirmed by ex vivo autoradiography. However, the PET signal in the eyes was unexpectedly higher than the autoradiography signal. The identification of radioligand-neuroreceptor binding by PET in the rabbit eyes is not specific enough.<\/jats:p>","DOI":"10.1159\/000081205","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T12:13:58Z","timestamp":1102076038000},"page":"255-263","source":"Crossref","is-referenced-by-count":5,"title":["Investigation of the Use of Positron Emission Tomography for Neuroreceptor Imaging in Rabbit Eyes"],"prefix":"10.1159","volume":"36","author":[{"given":"Wei-Fang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiichi","family":"Ishiwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Kiyosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Oda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Matsuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadayuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000265451"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00006231-199612000-00009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410150732"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109%2F15622970209150614"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00004850-199803003-00003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.1995.5.107"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1563-2571.2001.01024.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.1986.tb02850.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3940%2890%2990390-U"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00711177"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fcne.903310404"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2800%2902598-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006%2Fexer.1996.0272"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2897%2901450-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-328X%2801%2900249-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109%2F02713689109013865"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.100.1.64"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2800%2902553-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1006%2Fexer.1996.0352"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1006%2Fexer.2002.2048"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007020170001"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0969-8043%2899%2900152-9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2396%28199702%2925%3A2%3C147%3A%3AAID-SYN5%3E3.0.CO%3B2-C"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0969-8051%2800%2900081-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1109%2F42.192694"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0969-8051%2898%2900115-2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS1053-8119%2801%2992322-5"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03164856"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199701000-00015"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1109%2F23.596981"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:42:40Z","timestamp":1745466160000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2004,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081205","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2004]]}}}