{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:31:38Z","timestamp":1789194698662,"version":"build-2803163510"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Aldosterone blockade reduces morbidity and mortality in patients with heart failure. We studied the effects of eplerenone, a novel aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy after autoimmune myocarditis. Twenty-eight days after immunization, the surviving Lewis rats were randomized to 1 month\u2019s oral treatment with low-dose eplerenone (group L), high-dose eplerenone (group H) or vehicle (group V). Five of 15 (33%) rats in group V and 3 of 15 (20%) rats in group L died during the course of treatment. High-dose eplerenone significantly reduced cardiomyocyte hypertrophy, heart weight and heart weight to body weight ratio. Eplerenone improved left ventricular function in a dose-dependent manner. Central venous pressure and left ventricular end-diastolic pressure were lower, and \u00b1dP\/dt and fractional shortening were higher in group H than group V. Eplerenone also attenuated myocardial fibrosis and reduced left ventricular mRNA expressions of TGF-\u03b2&lt;sub&gt;1&lt;\/sub&gt; and collagen-III. Our results indicate that treatment with eplerenone improved left ventricular dysfunction and attenuated left ventricular remodeling in rats with heart failure.<\/jats:p>","DOI":"10.1159\/000081267","type":"journal-article","created":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T06:36:52Z","timestamp":1097476612000},"page":"81-88","source":"Crossref","is-referenced-by-count":27,"title":["Effects of Eplerenone, a Selective Aldosterone Blocker, on the Progression of Left Ventricular Dysfunction and Remodeling in Rats with Dilated Cardiomyopathy"],"prefix":"10.1159","volume":"73","author":[{"given":"Mir Imam Ibne","family":"Wahed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Tachikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushifusa","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI117269"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00795367"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra000050"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199909023411001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2802%2901965-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1527-3466.2001.tb00064.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0167-5273%2801%2900483-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000039104.56479.42"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2003.05.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa030207"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-1229%2890%2990039-S"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjp.0703450"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006%2Fabio.1987.9999"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-200000006-00006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00983.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00045415-200203000-00008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0008-6363%2896%2988507-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI117485"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199411103311907"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000039104.56479.42"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000068340.96506.0F"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:43:04Z","timestamp":1745466184000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081267","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}