{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:48Z","timestamp":1745554248450,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,12,15]],"date-time":"2004-12-15T00:00:00Z","timestamp":1103068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,12,15]],"date-time":"2004-12-15T00:00:00Z","timestamp":1103068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Cases of maternal thyroid dysfunction are not always clearly identified during pregnancy. We report here the case of a 36-year-old patient with a history of treated Graves\u2019 disease whose child successively presented with a hypo- and hyperthyroid dysfunction that was difficult to treat despite the administration of synthetic antithyroid drugs and \u03b2-blockers. The patient\u2019s thyroid hormone levels were normal during pregnancy, while still secreting anti-TSH-receptor autoantibodies. With time, these antibodies went from an inhibiting to a stimulating activity. Fetal monitoring using only ultrasonography had been proposed to the patient. With such a follow-up associated with fetal blood sampling it would have been possible to treat already &lt;i&gt;in utero&lt;\/i&gt; the thyroid dysfunction. The management of such patients is not limited to the follow-up of the maternal thyroid hormones, but should also evaluate the activity of the anti-TSH-receptor autoantibodies around the 28th week of amenorrhea and their effect on fetal blood. Fetal and neonatal thyroid dysfunctions have a major impact, but they can be detected and treated &lt;i&gt;in utero&lt;\/i&gt;. The clinical, laboratory and ultrasound follow-up makes it possible to monitor patients who are at risk and to propose a therapeutic and obstetrical management.<\/jats:p>","DOI":"10.1159\/000081361","type":"journal-article","created":{"date-parts":[[2004,12,17]],"date-time":"2004-12-17T21:59:19Z","timestamp":1103320759000},"page":"12-15","source":"Crossref","is-referenced-by-count":4,"title":["One Case of Fetal and Neonatal Variable Thyroid Dysfunction in the Context of Graves\u2019 Disease"],"prefix":"10.1159","volume":"20","author":[{"given":"Fran\u00e7oise","family":"Brand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Li\u00e9geois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Langer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00003081-199703000-00005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00003081-198309000-00012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F00016349109007160"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199905%2919%3A5%3C468%3A%3AAID-PD540%3E3.3.CO%3B2-R"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198607033150104"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2802%2901961-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198508293130907"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199410203311608"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-2243%2894%2990276-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199102213240811"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1754.2002.00741.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.107.4.e57"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.1999.9.179"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.2.514"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2896%2970405-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-994520"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0889-8529%2805%2970135-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.1999.9.1111"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.11.3633"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1995.tb06940.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2003.370"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2003.321"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:43:48Z","timestamp":1745466228000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,15]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081361","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2004,12,15]]}}}