{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:54:48Z","timestamp":1790240088609,"version":"4.1.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,12,15]],"date-time":"2004-12-15T00:00:00Z","timestamp":1103068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,12,15]],"date-time":"2004-12-15T00:00:00Z","timestamp":1103068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To assess the performance of screening for preeclampsia and intrauterine growth restriction by combining second trimester maternal serum screening and uterine Doppler ultrasound. &lt;i&gt;Methods:&lt;\/i&gt; A cohort of 2,615 women underwent both maternal serum screening (using human chorionic gonadotropin (hCG) and \u03b1-fetoprotein (AFP)), and second trimester uterine artery Doppler. The sensitivity, specificity and predictive value of different combinations of both tests were compared. &lt;i&gt;Results:&lt;\/i&gt; The mean values for hCG and AFP were significantly higher in women with subsequent preeclampsia (p &lt; 0.0003 and p &lt; 0.03, respectively). Taking into account obstetrical history, hCG and AFP levels, notching on uterine artery Doppler and parity, the adjusted odds ratios were significantly higher for a high level of hCG for preeclampsia, intrauterine growth restriction (IUGR) and pregnancy-induced hypertension. AFP level &gt;1.5 MoM (multiples of the median) was significantly correlated with subsequent IUGR. The presence of a uterine notch was associated with a significantly higher risk of both preeclampsia and IUGR. The combination of an elevated serum level and the presence of a uterine notch had a positive predictive value (PPV) for preeclampsia of 25 and 21% for hCG and AFP, respectively. The combination of a bilateral notch with a low level of hCG or a high level of AFP had a PPV for IUGR of 50 and 43%, respectively. The sensitivity of the different tests ranged from 2 to 40%. &lt;i&gt;Conclusion:&lt;\/i&gt; The combination of serum markers and abnormal uterine Doppler ultrasound improves the identification of women at risk for subsequent pregnancy complications. These results should encourage care providers to perform a uterine Doppler ultrasound when serum markers are abnormal. However, the sensitivity of these tests is too low to provide an efficient generalized screening.<\/jats:p>","DOI":"10.1159\/000081369","type":"journal-article","created":{"date-parts":[[2004,12,17]],"date-time":"2004-12-17T21:59:19Z","timestamp":1103320759000},"page":"48-53","source":"Crossref","is-referenced-by-count":67,"title":["Prediction of Preeclampsia or Intrauterine Growth Restriction by Second Trimester Serum Screening and Uterine Doppler Velocimetry"],"prefix":"10.1159","volume":"20","author":[{"given":"Fran\u00e7ois","family":"Audibert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehouda","family":"Benchimol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Benattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Champagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Frydman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2000.103890"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2899%2900467-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199912303412701"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2885%2992207-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2801%2901569-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2894%2992633-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2890%2991377-M"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.2001.00457.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1996.07030182.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2898%2970154-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2896%2970247-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000188939"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2897%2970512-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2898%2900112-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0412.1998.770404.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199902%2919%3A2%3C122%3A%3AAID-PD491%3E3.0.CO%3B2-R"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000264066"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0223%28200008%2920%3A8%3C652%3A%3AAID-PD882%3E3.3.CO%3B2-Y"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9378%2895%2991336-X"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1999.13010058.x"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:43:52Z","timestamp":1745466232000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,15]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081369","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,15]]}}}