{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:17:44Z","timestamp":1775189864796,"version":"3.50.1"},"reference-count":6,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Retinaldehyde and glycolic acid are both efficient in acne. &lt;i&gt;Objective:&lt;\/i&gt; To evaluate the efficacy and tolerability of a 0.1% retinaldehyde\/6% glycolic acid combination (Diacn\u00e9al&lt;sup&gt;\u00ae&lt;\/sup&gt;) for mild to moderate acne vulgaris. &lt;i&gt;Methods:&lt;\/i&gt; Overall physician and patient ratings of acne symptom severity and tolerance were performed at baseline, months 1, 2 and 3. &lt;i&gt;Results:&lt;\/i&gt; Mean numbers of papules, pustules and comedones were significantly reduced from month 1 onwards. A significant advantage of Diacn\u00e9al over vehicle was demonstrated on the percentages of patients with ongoing healing lesions at month 2, healing ancient lesions from month 1 and patients with \u2018important\/very important\u2019 global improvement from month 2 (50.0 vs. 26.3%) confirmed by patients at month 3 (86.1 vs. 58.8%). Products were well tolerated; only 1 patient had to stop the treatment. &lt;i&gt;Conclusions:&lt;\/i&gt; Diacn\u00e9al, a combination of 0.1% retinaldehyde\/6% glycolic acid, is effective and well tolerated in mild to moderate acne vulgaris.<\/jats:p>","DOI":"10.1159\/000081498","type":"journal-article","created":{"date-parts":[[2005,2,22]],"date-time":"2005-02-22T07:23:46Z","timestamp":1109057026000},"page":"14-21","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy and Safety of 0.1% Retinaldehyde\/ 6% Glycolic Acid (Diacn\u00e9al&lt;sup&gt;\u00ae&lt;\/sup&gt;) for Mild to Moderate Acne vulgaris"],"prefix":"10.1159","volume":"210","author":[{"given":"F.","family":"Poli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Ribet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lauze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Adhoute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Morinet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000067817"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000067825"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000051376"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.1999.00499.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2884%2980466-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0278-2391%2898%2990467-0"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:45:35Z","timestamp":1745466335000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":6,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081498","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}