{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:37:52Z","timestamp":1754109472616,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; It has been known for a long time that the topical use of retinoic acid (RA) produces mild depigmentation of human skin. However, RA has two major disadvantages for its utilisation as a topical depigmenting compound. First, RA can act as an irritant and can produce considerable erythema and exfoliation of skin. Second, RA has a relatively weak depigmenting ability compared to other known depigmenting chemicals. &lt;i&gt;Objective:&lt;\/i&gt; In this study, we show that RALGA, a combination of the less irritant retinoid retinaldehyde (RAL; 0.1%) and glycolic acid (6.4%), has a higher skin-depigmenting potential than RA 0.05% in the tail skin of C57BL\/6 mice. This effect was observed in reducing the number of functioning melanocytes and\/or in inhibiting their ability to synthesise melanin. In addition, the visually recognisable depigmenting effect of RALGA was evident earlier than that of RA, i.e. only after 1 week of application. RALGA may therefore serve as a depigmenting product for the treatment of skin hyperpigmentary disorders. Postacne hyperpigmented lesions represent a very common pigmentary problem among acne patients. RALGA may thus act as an anti-acne product, due to the presence of RAL \u2013 an RA precursor \u2013 which could simultaneously remove the postacne hyperpigmented lesions in such patients.<\/jats:p>","DOI":"10.1159\/000081499","type":"journal-article","created":{"date-parts":[[2005,2,22]],"date-time":"2005-02-22T07:23:46Z","timestamp":1109057026000},"page":"30-34","source":"Crossref","is-referenced-by-count":17,"title":["The Depigmenting Effect of RALGA in C57BL\/6 Mice"],"prefix":"10.1159","volume":"210","author":[{"given":"B.","family":"Kasraee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Sorg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-H.","family":"Saurat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.111.1.40"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1993.tb03169.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199202063260603"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1997.18111911.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000051381"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12363627"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000051373"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12412861"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.133.3.331"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-4827%2890%2990007-W"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12465072"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00498771"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000069938"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2165%2F00128071-200001020-00002"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81499","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:45:36Z","timestamp":1745466336000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":14,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081499","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2005]]}}}