{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:54:20Z","timestamp":1761216860346,"version":"3.40.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T00:00:00Z","timestamp":1105660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T00:00:00Z","timestamp":1105660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; We recently demonstrated that upregulation of the transforming growth factor (TGF)-\u03b21 inducible gene-h3 (\u03b2ig-h3) is associated with tubulointerstitial fibrosis (TIF) in a rat model of chronic cyclosporine A (CsA) nephrotoxicity. This study investigated the association between \u03b2ig-h3 expression and TIF during losartan treatment in this model. &lt;i&gt;Methods:&lt;\/i&gt; Adult Sprague-Dawley rats kept on a salt-depleted diet (0.05% sodium) were treated daily for 4 weeks with vehicle (olive oil, 1 ml\/kg), CsA (15\u00a0mg\/kg) or both CsA and losartan (10 mg\/kg in drinking water). The effect of losartan on \u03b2ig-h3 expression was evaluated using in situ hybridization, immunohistochemistry and immunoblotting. Histopathology, expressions of TGF-\u03b21 and intrarenal angiotensin II were compared across treatment groups. &lt;i&gt;Results:&lt;\/i&gt; Concurrent administration of losartan significantly attenuated \u03b2ig-h3 mRNA and protein expression within the tubulointerstitium of CsA-treated kidneys. This was accompanied by the retardation of TIF (18 \u00b1 5 vs. 39 \u00b1 5%, p &lt; 0.01 vs. CsA) and the expression of TGF-\u03b21 mRNA (336 \u00b1 49 vs. 685 \u00b1 63%, p &lt; 0.01 vs. CsA) and the number of angiotensin II-positive glomeruli (18 \u00b1 5 vs. 38 \u00b1 6, p &lt; 0.05 vs. CsA). &lt;i&gt;Conclusion:&lt;\/i&gt; Losartan is capable of abrogating the upregulation of TGF-\u03b21 and \u03b2ig-h3 expression, and this is associated with attenuated tubulointerstitial fibrosis in chronic CsA nephrotoxicity.<\/jats:p>","DOI":"10.1159\/000081793","type":"journal-article","created":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T08:44:42Z","timestamp":1106210682000},"page":"e9-e16","source":"Crossref","is-referenced-by-count":18,"title":["Blockade of Angiotensin II with Losartan Attenuates Transforming Growth Factor-\u03b21 Inducible Gene-h3 (\u03b2ig-h3) Expression in a Model of Chronic Cyclosporine Nephrotoxicity"],"prefix":"10.1159","volume":"99","author":[{"given":"Bo 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