{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:06:33Z","timestamp":1759961193607,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>Osmotic diuretics are therapeutic agents used to reduce endolymphatic hydrops. However, glycerol-induced change in endolymph volume is followed by a rebound phenomenon. In this study, we investigated the rebound phenomenon occurring with isosorbide, an osmotic diuretic used as a therapeutic agent for M\u00e9ni\u00e8re\u2019s disease in Japan. Forty guinea pigs underwent surgical obliteration of the endolymphatic sac. Thirty received isosorbide orally 1 month after surgery. These animals were sacrificed 3, 6, or 12 h after isosorbide intake. The remaining 10 animals served as controls. Quantitative assessment of changes in the endolymphatic space was performed light-microscopically. Isosorbide reduced cochlear endolymph volume, with a peak reduction 6 h after intake. Thereafter, no prominent rebound phenomenon was noted. Clinically, since isosorbide is orally administered every 8 h, rebound phenomenon need not be considered in the treatment with isosorbide.<\/jats:p>","DOI":"10.1159\/000081884","type":"journal-article","created":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T21:15:48Z","timestamp":1115241348000},"page":"291-296","source":"Crossref","is-referenced-by-count":10,"title":["Time Course of Dehydrating Effects of Isosorbide on Experimentally Induced Endolymphatic Hydrops in Guinea Pigs"],"prefix":"10.1159","volume":"66","author":[{"given":"Akinobu","family":"Kakigi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taizo","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasumi","family":"Higashiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,1,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3109%2F00016489009122516"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109%2F00016486609127084"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080%2F00016489950181369"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00453541"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F00016489509121910"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109%2F00016489209137456"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-5955%2899%2900180-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1975.42.2.0226"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00278481"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1023636620721"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1113%2Fjphysiol.2002.020818"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:17:24Z","timestamp":1745464644000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081884","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"type":"print","value":"0301-1569"},{"type":"electronic","value":"1423-0275"}],"subject":[],"published":{"date-parts":[[2004]]}}}