{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:44:05Z","timestamp":1779317045067,"version":"3.51.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>Prostaglandins have been used in experimental models and clinical studies for the therapy of sudden hearing loss and tinnitus with conflicting results. However, little is known about the rate-limiting enzymes of prostaglandin synthesis in the inner ear, the generally constitutively expressed cyclooxygenase 1 (COX-1) and the distress-inducible cycloxygenase 2 (COX-2). To extend our knowledge concerning the physiological expression and localization of these two enzymes, immunohistochemical stainings of the guinea pig cochlea were performed. Light microscopical analysis revealed a homogenous distribution of COX-1 within nearly all cell types of the organ of Corti, but no COX-1 expression in the cuticular plates of pillar cells. COX-2 was found to be expressed in all cell types, with much stronger expression in Hensen cells, neighboring Deiters cells and cuticular plates of outer hair cells. Both COX-1 and COX-2 immunoreactions were also found in the spiral ganglion. We conclude that both COX subtypes are expressed in the guinea pig cochlea under physiological conditions. The prominent expression of the distress-inducible COX-2 isoform in cell types under mechanical stress during noise reception might support the hypothesis of a cytoprotective function of COX products in hearing and in cellular stress situations like intense noise exposure.<\/jats:p>","DOI":"10.1159\/000081885","type":"journal-article","created":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T21:15:48Z","timestamp":1115241348000},"page":"297-301","source":"Crossref","is-referenced-by-count":18,"title":["Immunohistochemical Localization of Cyclooxygenase Isoforms in the Organ of Corti and the Spiral Ganglion Cells of Guinea Pig Cochlea"],"prefix":"10.1159","volume":"66","author":[{"given":"E.A.","family":"Ziegler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Brieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.R.","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.J.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,1,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.biochem.69.1.145"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI117620"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-0082%2800%2900027-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00405-002-0453-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004050050195"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1288%2F00005537-198905000-00014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00129492-200209000-00011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-5955%2803%2900217-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000046855"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2804%2900246-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1999.0587"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.1999.0721907.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00405-003-0648-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-5955%2898%2900027-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109%2F00016489609137914"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-5955%2899%2900049-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000074550"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1460-9568.2000.00263.x"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:17:24Z","timestamp":1745464644000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081885","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}