{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:00:14Z","timestamp":1775149214234,"version":"3.50.1"},"reference-count":7,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; This study investigates the association between cerebral vein thrombosis (CVT) and the mutations FV 1691A (factor V Leiden), PT 20210A and MTHFR 677TT and acquired factors including oral contraceptive (OC) use. &lt;i&gt;Methods:&lt;\/i&gt; 26 patients (21 females) and 217 healthy controls (134 females) were studied. Multiple regression analysis was performed. &lt;i&gt;Results:&lt;\/i&gt; The frequency of the three mutations in cases and controls were: PT 20210A, 23 versus 1%, odds ratio (OR) 21.40 (95% CI 4.29\u2013118.75), p &lt; 0.001; FV 1691A, 8 versus 1%, OR 5.94 (95% CI 0.66\u201346.9); MTHFR 677TT, 4 versus 7%, OR 0.54 (95% CI 0.03\u20134.08). OC use was more frequent in female patients over 14 years old than in controls (84 vs. 40%, OR 8.15, 95% CI 2.09\u201337.13, p &lt; 0.001). The model that best explained the thrombotic risk included PT 20210A and OC use. &lt;i&gt;Conclusions:&lt;\/i&gt; PT 20210A and OC use are the main thrombophilic risk factors predisposing to CVT and should be routinely investigated in patients with this disease.<\/jats:p>","DOI":"10.1159\/000081911","type":"journal-article","created":{"date-parts":[[2004,11,9]],"date-time":"2004-11-09T07:56:35Z","timestamp":1099986995000},"page":"49-52","source":"Crossref","is-referenced-by-count":44,"title":["Prothrombin 20210A and Oral Contraceptive Use as Risk Factors for Cerebral Venous Thrombosis"],"prefix":"10.1159","volume":"19","author":[{"given":"Telma","family":"Gadelha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Andr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreza A.V.","family":"Juc\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio","family":"Nucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2F369064a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0595-111"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199806183382502"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0404.2000.102001031.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1538-7836.2004.00785.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2894%2990286-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.2.5599.199"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:17:34Z","timestamp":1745464654000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081911","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}