{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:50:22Z","timestamp":1760853022680,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Quinupristin-dalfopristin (Q-D) is a mixture of quinupristin and dalfopristin, which are semisynthetic antibiotics of streptogramin groups B and A, respectively. &lt;i&gt;Methods:&lt;\/i&gt; We compared the effect of Q-D to that of vancomycin (VCM) in murine models of hematogenous pulmonary infections caused by methicillin-resistant &lt;i&gt;Staphylococcus aureus&lt;\/i&gt; (MRSA) and VCM-insensitive &lt;i&gt;S.\u00a0aureus&lt;\/i&gt; (VISA). &lt;i&gt;Results:&lt;\/i&gt; Treatment with Q-D resulted in a significant decrease in the number of viable bacteria in the lungs of mice in an MRSA infection model [Q-D 100 mg\/kg, Q-D 10 mg\/kg, VCM and control (mean \u00b1 SEM): 2.99 \u00b1 0.44, 6.38 \u00b1 0.32, 5.75 \u00b1 0.43 and 8.40 \u00b1 0.14 log&lt;sub&gt;10&lt;\/sub&gt; CFU\/lung, respectively]. Compared with VCM, high-dose Q-D significantly reduced the number of bacteria detected in the VISA hematogenous infection model [Q-D 100 mg\/kg, Q-D 10 mg\/kg, VCM and control (mean \u00b1 SEM): 5.17 \u00b1 0.52, 7.03 \u00b1 0.11, 7.10 \u00b1 0.49 and 7.18 \u00b1 0.36 log&lt;sub&gt;10&lt;\/sub&gt; CFU\/lung, respectively]. Histopathological examination confirmed the effect of Q-D. &lt;i&gt;Conclusion:&lt;\/i&gt; Our results suggest that Q-D is potent and effective in the treatment of MRSA and VISA hematogenous pulmonary infections.<\/jats:p>","DOI":"10.1159\/000081948","type":"journal-article","created":{"date-parts":[[2004,11,9]],"date-time":"2004-11-09T07:56:35Z","timestamp":1099986995000},"page":"260-264","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of Quinupristin-Dalfopristin against Methicillin-Resistant &lt;i&gt;Staphylococcus aureus&lt;\/i&gt; and Vancomycin-Insensitive &lt;i&gt;S. aureus&lt;\/i&gt; in a Model of Hematogenous Pulmonary Infection"],"prefix":"10.1159","volume":"50","author":[{"given":"Katsunori","family":"Yanagihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Higashiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitsugu","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Hirakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Tomono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ichi","family":"Kadota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2F40.1.135"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199902183400701"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1086%2F367662"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-002-1358-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.46.10.3288-3291.2002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.45.11.3234-3237.2001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000048530"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0691.2000.00152.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2801%2905410-1"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/81948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:18:10Z","timestamp":1745464690000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000081948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2004,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000081948","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2004]]}}}