{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:50:19Z","timestamp":1761058219319,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Genomics"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To investigate the current prevalence of \u03b1-thalassaemia in the population of Western Australia, which has received substantial immigration from South-East Asia during the last 30 years. &lt;i&gt;Method:&lt;\/i&gt; Over a 1-year period commencing July 2002, \u03b1-thalassaemia DNA testing was performed on 920 blood samples received from the Migrant Health Service, referring doctors or pathology laboratories in Western Australia. Molecular testing for \u03b1-thalassaemia was performed on extracted DNA for single and double \u03b1-globin gene deletions and mutations by PCR. &lt;i&gt;Results:&lt;\/i&gt; An \u03b1-globin gene abnormality was detected in 35.4% (326\/920) of samples. There were 177 cases (50.6%) with a single gene deletion \u03b1&lt;sup&gt;+&lt;\/sup&gt;-thalassaemia, most commonly \u20133.7 kb, and 102 cases (31.2%) with double \u03b1-gene deletions (\u03b1&amp;#8304;-thalassaemia), including 7 cases of HbH disease. &lt;i&gt;Conclusion:&lt;\/i&gt; Overall, the findings amount to 1.7 new cases of \u03b1-thalassaemia per 10,000 population in the 12-month period and demonstrate that \u03b1-thalassaemia is an increasingly common disorder in the Western Australian population. This has important implications for community outreach programmes, genetic counselling and the screening of at-risk populations.<\/jats:p>","DOI":"10.1159\/000082264","type":"journal-article","created":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T11:44:58Z","timestamp":1107776698000},"page":"211-215","source":"Crossref","is-referenced-by-count":5,"title":["A Community Profile of Alpha Thalassaemia in Western Australia"],"prefix":"10.1159","volume":"7","author":[{"given":"J.F.","family":"Prior","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.H.","family":"Bittles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.N.","family":"Erber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016%2FS0268-960X%2802%2900061-9"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1111%2Fj.1365-2141.1993.tb04639.x"}],"container-title":["Public Health Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:21:39Z","timestamp":1745464899000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000082264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":2,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000082264","archive":["Portico"],"relation":{},"ISSN":["1662-4246","1662-8063"],"issn-type":[{"type":"print","value":"1662-4246"},{"type":"electronic","value":"1662-8063"}],"subject":[],"published":{"date-parts":[[2004]]}}}