{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:49:01Z","timestamp":1782859741068,"version":"3.54.5"},"reference-count":8,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>The aim of this study was to evaluate the difference in the expression of mRNA of two types of calcium channels between longitudinal and circular muscle layer of rat myometrium during pregnancy. Changes in the expressions of the mRNA encoding L-type (\u03b11C) and T-type (\u03b11G, \u03b11H, and \u03b11I) calcium channels in longitudinal and circular smooth muscle cells of the rat myometrium were examined using a comparative kinetic RT\/PCR method. During the course of pregnancy, \u03b11C mRNA expression showed an N-shaped change in longitudinal muscle, but simply increased after mid-pregnancy in circular muscles. The mRNAs for \u03b11G and \u03b11H, but not that for \u03b11I, were expressed in both longitudinal and circular smooth muscle. In longitudinal muscle, the change in \u03b11H mRNA was similar to that in \u03b11C mRNA during gestation, but the expression of \u03b11G mRNA changed significantly only at term (day 22). In circular muscle, \u03b11H mRNA expression was stable at any stage during pregnancy, but \u03b11G mRNA significantly increased on day 15 and at term. No relationship was observed between voltage-dependent calcium-channel mRNA expressions and either proliferation or hypertrophy of circular muscle during pregnancy. These results show (a) that during pregnancy, the expression levels of L-type channels change dynamically, and it may contribute directly to the regulation of cell excitability, and (b) that the T-subtype that increases during pregnancy differs between longitudinal and circular muscle cells, although their functions remain unclear.<\/jats:p>","DOI":"10.1159\/000082333","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T12:13:58Z","timestamp":1102076038000},"page":"80-85","source":"Crossref","is-referenced-by-count":19,"title":["Differential Expression of L- and T-Type Calcium Channels between Longitudinal and Circular Muscles of the Rat Myometrium during Pregnancy"],"prefix":"10.1159","volume":"59","author":[{"given":"Tsuyako","family":"Ohkubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Kawarabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-2999%2895%2900089-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1085%2Fjgp.110.5.565"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod51.5.993"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.13.7627"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1113%2Fjphysiol.2001.013269"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-3495%2898%2977893-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fnar%2F20.18.4939"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fjcla.1030"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:22:50Z","timestamp":1745464970000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000082333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000082333","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}