{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T23:48:00Z","timestamp":1772063280229,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>We compared the intact \u03b17 nicotinic acetylcholine receptor (\u03b17nAChR) protein levels in the peripheral blood leukocytes in 15 Alzheimer\u2019s disease (AD) patients and 13 normal elderly control subjects. Demographic data and Mini-Mental State Examination (MMSE) scores were obtained. Western blot analysis for \u03b17nAChR protein levels in peripheral blood leukocytes was performed. There were no significant differences in sex and age between the AD and control groups. The mean MMSE score of the AD subjects was significantly lower than that of the normal control subjects (15.4 \u00b1 5.5 vs. 28.5 \u00b1 1.9 respectively; p &lt; 0.001). The median value of normalized \u03b17nAChR protein levels (optical density, arbitrary unit) of the AD group was significantly higher than that of the normal control group (0.6923 vs. 0.4803 respectively; p = 0.045, Mann-Whitney U test). The normalized \u03b17nAChR protein levels showed a significant inverse correlation with the MMSE scores (Spearman rho = \u20130.45; p = 0.016; n = 28). Receiver Operating Characteristic curve analyses showed that the area under curve was 0.72 (95% CI 0.52\u2013 0.87). If the cut-off of the \u03b17nAChR protein level was &gt;0.312, the sensitivity, specificity, positive predictive value and negative predictive value would be 80, 39, 60 and 63%, respectively. These findings showed that the \u03b17nAChR protein levels would be a potentially useful diagnostic marker for AD.<\/jats:p>","DOI":"10.1159\/000082661","type":"journal-article","created":{"date-parts":[[2004,12,14]],"date-time":"2004-12-14T13:00:22Z","timestamp":1103029222000},"page":"106-112","source":"Crossref","is-referenced-by-count":27,"title":["Increased Alpha 7 Nicotinic Acetylcholine Receptor Protein Levels in Alzheimer\u2019s Disease Patients"],"prefix":"10.1159","volume":"19","author":[{"given":"L.W.","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.S.K.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.K.Y.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.H.S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002130050667"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080%2F14622200110050213"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0741-8329%2801%2900130-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fneu.10151"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1124%2Fmol.63.2.311"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-3223%2800%2901116-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-3223%2800%2901125-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-328X%2899%2900030-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.2000.0740237.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0278-5846%2886%2990005-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0028-3908%2800%2900153-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-4679%28199003%2946%3A2%3C190%3A%3AAID-JCLP2270460211%3E3.0.CO%3B2-M"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1192%2Fbjp.140.6.566"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm0896-864"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.57.1.100"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.275.8.5626"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.2000.0751155.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.081553598"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2800%2900124-X"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature01339"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.327.7407.128"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.289.21.2819"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000080502"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:25:40Z","timestamp":1745465140000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000082661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":23,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000082661","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}