{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:45:15Z","timestamp":1790934315905,"version":"4.1.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Introduction:<\/i> The aim of this study is to compare the histological results of a prostate needle biopsy scheme of 12 and 18 cores used in 372 consecutive patients submitted to an early stage diagnosis programme for prostate cancer (PCa). <i>Materials and Methods:<\/i> From February 2002 to July 2003 a transperineal TRUS-guided prostate needle biopsy was performed in 372 patients aged 40\u201373. Indications for biopsy were: suspected DRE, total PSA (PSAt) >10\u00a0ng\/ml; PSAt equal to 4\u201310, 2.6\u20133.9, \u22642.5 ng\/ml and PSA F\/T <25%, <20% and <15%, respectively. In 256 patients, we performed 12 cores and in 116 cases 18 cores. <i>Results:<\/i> 159 (42.7%) patients were diagnosed with PCa, 138 (37%) with BPH, 58 (15.7%) with chronic prostatitis, 15 (4%) with a HGPIN, 2 (0.6%) with ASAP. In patients that underwent 12 and 18 cores the incidence of PCa was 39.8 and 49%; the incidence of PCa in patients with PSA \u226410 and >10 ng\/ml submitted to 12 and 18 cores was 35 vs. 47% and 57.8 vs. 52%, respectively. The preponderance of clinical stage T1c was 50% (12 cores) vs. 72% (18 cores). The median bioptic Gleason score in both groups resulted 6.6 (12 cores) and 6 (18 cores). In 110 (12 bioptic cores) and in 30 (18 bioptic cores) patients that underwent a RRP, the pTNM proved a significant clinical neoplasm (Gleason score \u22676 and\/or tumoral volume >0.5\u00a0cm<sup>3<\/sup>) in the first group in all cases, while in the second group in 28\/30 (94%) cases. <i>Conclusions:<\/i> Extended schemes of prostate needle biopsy of 18 or more cores increases the PCa diagnosis in early stage and should be adopted for young patients with a PSA <10 ng\/ml, negative DRE and in case of rebiopsies.<\/jats:p>","DOI":"10.1159\/000082703","type":"journal-article","created":{"date-parts":[[2005,2,15]],"date-time":"2005-02-15T08:04:21Z","timestamp":1108454661000},"page":"19-22","source":"Crossref","is-referenced-by-count":24,"title":["Prostate Needle Biopsy: 12 vs. 18 Cores \u2013 Is It Necessary?"],"prefix":"10.1159","volume":"74","author":[{"given":"Pietro","family":"Pepe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Aragona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000049878"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200008000-00029"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199701000-00059"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819950115%2975%3A2%3C530%3A%3AAID-CNCR2820750216%3E3.0.CO%3B2-Y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2897%2900306-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000049787"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.pcan.4500647"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00345-003-0341-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2803%2900108-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2802%2901625-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200112000-00036"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410x.2000.00558.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200107000-00024"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200001000-00037"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0302-2838%2803%2900139-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820001015%2989%3A8%3C1810%3A%3AAID-CNCR22%3E3.0.CO%3B2-9"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200108000-00003"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:26:13Z","timestamp":1745465173000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000082703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000082703","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}