{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:20:58Z","timestamp":1767831658583,"version":"3.49.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Objective and Methods:&lt;\/i&gt; To examine the involvement of neurotrophic factor receptors in the testis with acute experimental testicular torsion, the expression of tyrosine kinase receptors (trk) A and B, and p75 nerve growth factor receptor (NGFR) were studied in the rat testis with ischemia\/reperfusion (I\/R) injury, using Western blotting and immunohistochemistry. Apoptosis was detected using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) method. &lt;i&gt;Results:&lt;\/i&gt; There was a significant increase in TUNEL-positive reaction in spermatogonia in the seminiferous tubules in rat testes after testicular torsion. Western blot analysis showed that trk A expression reached a significant peak at 12 h after reperfusion (p &lt; 0.01), as compared to sham-operated controls, whereas trk B was not increased in the testis after I\/R. Constitutive expression of p75 NGFR was at or below the level detectable by Western blot analysis, and it remained unchanged in the testis after I\/R. Immunohistochemistry demonstrated that after I\/R trk A expression was increased in spermatocytes and spermatids in the seminiferous tubules, in contrast to the basal location of the TUNEL-positive reaction. Immunoreactivity of trk B was seen mainly in the interstitial cells in the sham-operated testis, and its localization was not changed after I\/R. &lt;i&gt;Conclusion:&lt;\/i&gt; It is postulated that trk A and B, but not p75 NGFR, are involved differently in the survival of testicular cells during acute experimental testicular torsion. In particular, increased trk A seems to be related to germ cell survival following I\/R.<\/jats:p>","DOI":"10.1159\/000082715","type":"journal-article","created":{"date-parts":[[2005,2,15]],"date-time":"2005-02-15T08:04:21Z","timestamp":1108454661000},"page":"79-85","source":"Crossref","is-referenced-by-count":8,"title":["Enhanced Expression of Tyrosine Kinase Receptor A in Germ Cells of Rat Testis with Acute Experimental Testicular Torsion"],"prefix":"10.1159","volume":"74","author":[{"given":"Changjong","family":"Moon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumioki","family":"Yasuzumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Okura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heechul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meejung","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taekyun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM197702102960611"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109%2F00365599109024555"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod57.6.1267"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod63.5.1465"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007950100018"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0896-6273%2893%2990306-C"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.85.8.2628"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod51.2.214"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.2154035"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0303-7207%2801%2900551-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1071%2FRD9961075"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2800%2901253-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod65.2.514"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-6147%2890%2990068-J"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00441-002-0547-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumupd%2F5.5.399"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.ne.18.030195.001255"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0306-4522%2892%2990292-A"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.117.3.629"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3940%2892%2990885-B"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:26:21Z","timestamp":1745465181000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000082715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000082715","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}