{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:09:56Z","timestamp":1745554196108,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims: &lt;\/i&gt;To evaluate the functional outcome of a reconstruction by a free vascularized jejunal transplant combined with a voice prosthesis after chemoradiotherapy and surgery for proximal oesophageal or hypopharyngeal cancer. &lt;i&gt;Methods: &lt;\/i&gt;Seven patients (6 men, mean age 52 years, range 28\u201370) with squamous cell cancer in the proximal oesophagus (n = 6) or the hypopharynx received preoperative chemoradiotherapy (40.8 Gy, cisplatinum and 5-FU) followed by a circumferential pharyngolaryngectomy and resection of the proximal oesophagus. A single-stage reconstruction was carried out with a free jejunal transplant using a microsurgical technique. A tracheojejunal puncture and insertion of a voice prosthesis (Provox I) was performed after 3 months in suitable cases. &lt;i&gt;Results: &lt;\/i&gt;All operations had a per- and postoperative uneventful course. Five patients were alive after a mean follow-up time of 5 years and 7 months after surgery (range 3 years 4 months to 7 years 10 months), while 2 patients died from metastases within 2 years after surgery. Postoperative examination showed histopathological down-staging in all cases. Relief of dysphagia was achieved in most cases. Good or average speech was recorded in 3 patients. &lt;i&gt;Conclusion: &lt;\/i&gt;Reconstruction after radical resection for proximal oesophageal and hypopharyngeal cancer can be carried out with low mortality, acceptable morbidity and a promising functional outcome.<\/jats:p>","DOI":"10.1159\/000082753","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T21:06:35Z","timestamp":1103749595000},"page":"426-433","source":"Crossref","is-referenced-by-count":11,"title":["Functional Long-Term Outcome of a Free Jejunal Transplant Reconstruction following Chemoradiotherapy and Radical Resection for Hypopharyngeal and Proximal Oesophageal Carcinoma"],"prefix":"10.1159","volume":"21","author":[{"given":"Henrik","family":"Bergquist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasse","family":"Ejnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingemar","family":"Fogdestam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Mercke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Lundell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Ruth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchsurg.136.10.1164"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9610%2801%2900763-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-4975%2801%2903167-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F02844319850158651"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00268-001-0268-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1258%2F00222150260293655"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS1010-7940%2801%2900618-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004050100324"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2168.1996.02323.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1288%2F00005537-198809000-00001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1258%2F0022215001906282"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F85.5.365"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02303643"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:26:42Z","timestamp":1745465202000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000082753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":13,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000082753","archive":["Portico"],"relation":{},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"type":"print","value":"0253-4886"},{"type":"electronic","value":"1421-9883"}],"subject":[],"published":{"date-parts":[[2004]]}}}