{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:24:56Z","timestamp":1759847096377,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Objectives:<\/i>Chronic occult blood loss from the gastrointestinal tract is a recognized major cause of iron-deficiency anemia. After conventional investigation of the upper and lower parts of the gastrointestinal tract, the source of bleeding remains unidentified in ~10% of these patients. We evaluated the diagnostic yield of capsule endoscopy from patients enrolled in clinical studies due to persistent or recurrent iron-deficiency anemia. <i>Methods:<\/i> In this large cohort study, patients with obscure gastrointestinal bleeding were identified in a company-sponsored clinical study (Given Imaging, Ltd.) database which contains data from >50 clinical studies. Information on suitable patients was derived from 31 of them. Each subject swallowed an M2A<sup>\u00ae<\/sup> Given Capsule containing a miniature video camera, batteries, a transmitter and an antenna. Recording time was ~8 h. The capsule was excreted naturally in the patient\u2019s bowel movement, and the data it transmitted were retrieved and interpreted the next day. <i>Results:<\/i> 293 patients were studied (135 males, 46.1%, mean age 59.4 \u00b1 16.8 years) whose mean number of bleeding episodes was 4.3 \u00b1 5.5 and mean hemoglobin level was 9.8 \u00b1 2.4 g\/dl. The average number of diagnostic procedures per patient prior to the capsule endoscopy study was 5.59. Capsule endoscopy detected definitive findings in 213\/293 patients (72%) and findings missed by other diagnostic procedures in 22\/293 patients (8%). Neither capsule endoscopy nor the other diagnostic procedures yielded diagnoses in 58\/293 patients (20%). <i>Conclusions:<\/i> Capsule endoscopy has a high diagnostic yield in evaluating patients with obscure gastrointestinal bleeding.<\/jats:p>","DOI":"10.1159\/000082834","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T21:06:35Z","timestamp":1103749595000},"page":"201-206","source":"Crossref","is-referenced-by-count":26,"title":["Diagnostic Yield of Capsule Endoscopy in Obscure Gastrointestinal Bleeding"],"prefix":"10.1159","volume":"70","author":[{"given":"Zvi","family":"Fireman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shosh","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199312023292303"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2802%2901226-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2800%2970430-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-9260%2897%2980075-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199907013410107"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2003-38767"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2003-37313"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2003.01556.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.42.3.421"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2898%2970347-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2898%2970221-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2887%2971682-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2003-44582"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.247.6.789"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0735-6757%2888%2990055-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-198611000-00004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9610%2892%2990259-T"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9610%2892%2990258-S"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2F35013140"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9270%2802%2905438-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2002-33446"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2002.35988"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1067%2Fmge.2002.126906"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2003.11.057"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200409000-00019"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2003.12.057"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:27:10Z","timestamp":1745465230000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000082834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000082834","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2004]]}}}