{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:00:46Z","timestamp":1761894046534,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>\u03b2-Adrenoreceptor antagonistic activity of a newly synthesized compound was evaluated in vivo by measuring the mean arterial blood pressure and heart rate of urethane-anesthetized rats treated with isoprenaline. In vitro \u03b2&lt;sub&gt;1&lt;\/sub&gt;-, \u03b2&lt;sub&gt;2&lt;\/sub&gt;- and \u03b2&lt;sub&gt;3&lt;\/sub&gt;-antagonism was studied using isolated rat right atria, isolated rat uterus and isolated rat colon preparations, respectively, in comparison to isoprenaline response. DPJ 904 (1, 3 and 10 mg\/kg, i.v.) produced dose-dependent hypotensive and bradycardia response in anesthetized rat. DPJ 904 (1, 3 and 10 mg\/kg, i.v.) significantly inhibited both the tachycardial effects and hypotensive response induced by isoprenaline. DPJ 904-antagonized isoprenaline induced positive chronotropic effects of isolated rat right atria and a uterine relaxant effect indicating \u03b2&lt;sub&gt;1&lt;\/sub&gt;- and \u03b2&lt;sub&gt;2&lt;\/sub&gt;-blockade. The parallel shift to the right of the concentration-response curve of isoprenaline in the presence of DPJ 904 in KCl (30 mmol\/l) induced contraction of the rat colon suggesting that DPJ 904 also possessed \u03b2&lt;sub&gt;3&lt;\/sub&gt;-adrenoreceptor antagonistic activity. The selectivity to \u03b2&lt;sub&gt;1&lt;\/sub&gt;-adrenoreceptor was nearly 20.5 times greater than to \u03b2&lt;sub&gt;2&lt;\/sub&gt;-adrenoreceptor. The present study indicates that DPJ 904 possesses \u03b2-adrenoreceptor antagonistic activity with slightly more affinity to the \u03b2&lt;sub&gt;1&lt;\/sub&gt;-adrenoreceptor subtype.<\/jats:p>","DOI":"10.1159\/000082861","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T10:00:23Z","timestamp":1104400823000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Study of \u03b2-Adrenoreceptor Antagonistic Activity of DPJ 904 in Rats"],"prefix":"10.1159","volume":"74","author":[{"given":"K.","family":"Nandakumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.K.","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randhir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Mohite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Bodhankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.P.","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohane S.","family":"Coumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Balaraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-6147%2897%2989942-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.157.21.2413"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-827X%2803%2900083-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-199907000-00003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-3623%2801%2900076-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0033-0620%2880%2990011-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2299%28200002%2949%3A2%3C94%3A%3AAID-DDR3%3E3.0.CO%3B2-V"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:27:18Z","timestamp":1745465238000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000082861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000082861","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2005]]}}}