{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:30:23Z","timestamp":1758990623560,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Superantigens are suspected to be the potent and lethal pathogens of gram-positive sepsis, and a new therapy that targeted to superantigens are required. &lt;i&gt;Methods:&lt;\/i&gt; A mixed infection model was developed in rabbits by the cecal ligation and puncture associated with the intraperitoneal injection of&lt;i&gt; Staphylococcus aureus&lt;\/i&gt;, which produces toxic shock syndrome toxin 1 (TSST-1). Animals were also hemoperfused with a superantigen-adsorbing device (SAAD), or a control column. &lt;i&gt;Results:&lt;\/i&gt; The model animals revealed multiple organ failure and died 6\u201312 h after the injection of &lt;i&gt;S. aureus&lt;\/i&gt;. The plasma levels of TSST-1, but not of lipopolysaccharide (LPS), significantly (p &lt; 0.01) and inversely correlated with mean arterial pressure (r = -0.63). Plasma TSST-1 level was significantly reduced and shock-onset time was significantly retarded in the SAAD treated group, although the survival time was not significantly affected. &lt;i&gt;Conclusions:&lt;\/i&gt; The animal model developed could serve as a model for sepsis. It is suggested that there is the potential application of SAAD in treating superantigen-related sepsis.<\/jats:p>","DOI":"10.1159\/000083206","type":"journal-article","created":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T21:15:48Z","timestamp":1115241348000},"page":"119-127","source":"Crossref","is-referenced-by-count":5,"title":["Mixed Bacterial Infection Model of Sepsis in Rabbits and Its Application to Evaluate Superantigen-Adsorbing Device"],"prefix":"10.1159","volume":"23","author":[{"given":"Mayumi","family":"Fukuyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Shibayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199305203282008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.154.1.26"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0195-6701%2895%2990315-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199102143240701"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2902712-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-5520%2805%2970082-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1139%2Fcjm-45-3-250"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2965800-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1526-0968.2001.005002111.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000014440"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS1201-9712%2803%2990038-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00024382-199801000-00001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-4804%2880%2990037-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0923-1137%2891%2990152-E"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089%2Fjir.1997.17.229"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.1830270405"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1042%2FCS20000017"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:30:12Z","timestamp":1745465412000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000083206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000083206","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"type":"print","value":"0253-5068"},{"type":"electronic","value":"1421-9735"}],"subject":[],"published":{"date-parts":[[2005]]}}}