{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:01:46Z","timestamp":1789664506035,"version":"4.0.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Background:<\/i> The laryngeal mask airway (LMA<sup>TM<\/sup>, Laryngeal Mask Co. Ltd, Jersey, UK) is a supraglottic device used to administer positive pressure ventilation (PPV) in adults, pediatric and neonatal patients. <i>Objectives:<\/i> To avoid endotracheal intubation, we evaluated the feasibility and practicality of administering surfactant via the LMA<sup>TM<\/sup> in preterm infants with respiratory distress syndrome (RDS). <i>Methods:<\/i> Infants less than 72 h old with a gestational age of \u226435 weeks and a birth weight of >800 g, treated with nasal continuous positive airway pressure (CPAP, 5 cm H<sub>2<\/sub>O) for RDS were eligible for inclusion in the study if the arterial-to-alveolar oxygen tension ratio (a\/APO<sub>2<\/sub>) was <0.20 over a period of >60 min. <i>Results:<\/i> Eight preterm infants, median gestational age 31 (range 28\u201335) weeks; birth weight 1,700 (880\u20132,520) g, treated with nasal CPAP for RDS were enrolled. Three hours after surfactant instillation, the mean a\/APO<sub>2<\/sub> was significantly increased (0.13 \u00b1 0.04 to 0.34 \u00b1 0.11; p < 0.01) without complications. <i>Conclusions:<\/i> The LMA<sup>TM<\/sup> may be a useful and noninvasive conduit for the administration of surfactant therapy. A large randomized comparative clinical trial will be required to confirm the efficacy of this technique.<\/jats:p>","DOI":"10.1159\/000083370","type":"journal-article","created":{"date-parts":[[2005,2,15]],"date-time":"2005-02-15T08:04:21Z","timestamp":1108454661000},"page":"217-220","source":"Crossref","is-referenced-by-count":108,"title":["Laryngeal Mask Airway Used as a Delivery Conduit for the Administration of Surfactant to Preterm Infants with Respiratory Distress Syndrome"],"prefix":"10.1159","volume":"87","author":[{"given":"Daniele","family":"Trevisanuto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Grazzina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Ferrarese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Micaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandy","family":"Verghese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Zanardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199303253281208"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.103.2.e24"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2003.038430"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00000542-200308000-00005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-3782%2800%2900122-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000244286"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080%2F080352500750028195"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000240546"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211103"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00003246-198710000-00005"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:32:14Z","timestamp":1745465534000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000083370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000083370","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}