{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:18:50Z","timestamp":1784128730257,"version":"3.55.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T00:00:00Z","timestamp":1106179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T00:00:00Z","timestamp":1106179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Useful markers of bone resorption are needed for hemodialysis patients with renal osteodystrophy. This study investigated the use of a new immunoassay for cross-linked N-terminal telopeptide of type 1 collagen to assess bone changes in hemodialysis patients. &lt;i&gt;Methods:&lt;\/i&gt; Radial bone mineral density was examined in 178 hemodialysis patients at baseline and after 12 months. Serum levels of N-terminal telopeptide and other markers were measured. &lt;i&gt;Results:&lt;\/i&gt; The annual percent change of radial bone mineral density was negatively correlated with the levels of N-terminal telopeptide, intact osteocalcin, tartrate-resistant acid phosphatase, bone-specific alkaline phosphatase, and intact parathyroid hormone. The annual percent change of radial bone mineral density showed a stronger correlation with N-terminal telopeptide levels than with the other markers, except for intact parathyroid hormone. Also, intact parathyroid hormone and N-terminal telopeptide levels showed a stronger correlation than that of either tartrate-resistant acid phosphatase or cross-linked carboxyterminal telopeptide of type 1 collagen with intact parathyroid hormone. &lt;i&gt;Conclusion:&lt;\/i&gt; Serum N-terminal telopeptide may be the most useful bone resorption marker in renal osteodystrophy and its use combined with bone formation markers may improve the management of this condition.<\/jats:p>","DOI":"10.1159\/000083418","type":"journal-article","created":{"date-parts":[[2005,1,20]],"date-time":"2005-01-20T17:13:04Z","timestamp":1106241184000},"page":"c78-c85","source":"Crossref","is-referenced-by-count":7,"title":["Serum Cross-Linked N-Terminal Telopeptide of Type I Collagen for Evaluation of Renal Osteodystrophy in Hemodialysis Patients"],"prefix":"10.1159","volume":"99","author":[{"given":"Ayumu","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yorioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zentaro","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihisa","family":"Takasugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200005183422003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fjbmr.5650020617"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1993.350"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1995.201"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F15.5.659"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00461.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2896%2900387-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.1998.13.9.1431"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0953-6205%2803%2900034-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.4.5893.643"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00222.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02411252"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199702000-00034"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.79.6.1693"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01623388"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.80.8.2447"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.2000.15.3.594"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS8756-3282%2899%2900270-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.48.32347"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.1999.14.11.1902"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:32:56Z","timestamp":1745465576000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000083418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,20]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000083418","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,20]]}}}