{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:15:01Z","timestamp":1789020901406,"version":"build-2803163510"},"reference-count":10,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Vulvar lichen sclerosus (LS) still presents a therapeutic challenge. &lt;i&gt;Questions:&lt;\/i&gt; The aim of the present study was to investigate whether there is a correlation between preoperative histopathological findings in female LS and long-term results after cryosurgery and intralesional steroid injections. &lt;i&gt;Material and Methods:&lt;\/i&gt; 22 females with LS, mean age 65.3 \u00b1 10.5 years, were treated with cryosurgery (\u2013186\u00b0C) using the contact method with 1 freeze-thaw cycle per lesion and intralesional triamcinolone acetonide injection. The time between surgery and follow-up examination was 27.8 \u00b1 14.6 months. We compared the clinical outcome and the thickness of the epidermis, the zone of sclerosis and the inflammatory infiltrate in biopsy specimens taken before treatment. &lt;i&gt;Results:&lt;\/i&gt; In 14 of 22 patients, a relapse after cryosurgery occurred (median after 7.5 months). Patients would \u2018moderately\u2019 recommend cryosurgery for LS (2.2 \u00b1 0.9; minimum: 0, optimum: 4). Pruritus was significantly reduced (visual analog scale: preoperative 7.1 \u00b1 2.6 vs. postoperative 2.0 \u00b1 2.4; p = 0.001) even in patients with relapse (preoperative 7.6 \u00b1 2.4 vs. postoperative 3.1 \u00b1 2.28; p = 0.001). Women with relapse showed a significantly higher composed thickness of epidermis, sclerosis and inflammatory infiltrate (430 \u00b1 139.0 \u00b5m) than those without relapse (314 \u00b1 41.2 \u00b5m; p\u00a0= 0.046). &lt;i&gt;Conclusion:&lt;\/i&gt; In our patients, cryosurgery and intralesional steroid injections were efficient in the treatment of LS. Patients showing relapse had a thicker epidermis and a stronger inflammatory infiltrate. Therefore a treatment of LS should be performed at an early stage of the disease.<\/jats:p>","DOI":"10.1159\/000083513","type":"journal-article","created":{"date-parts":[[2005,3,21]],"date-time":"2005-03-21T15:12:21Z","timestamp":1111417941000},"page":"218-222","source":"Crossref","is-referenced-by-count":26,"title":["The Outcome after Cryosurgery and Intralesional Steroid Injection in Vulvar Lichen sclerosus Corresponds to Preoperative Histopathological Findings"],"prefix":"10.1159","volume":"210","author":[{"given":"Markus","family":"St\u00fccker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Grape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk Georges","family":"Bechara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Altmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.2003.01211.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004040100209"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000065846"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.2001.00907.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.05012.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2897%2981071-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1610-0387.2003.t01-1-02511.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1980.tb01690.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1610-0387.2003.03517.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.1994.tb01167.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:33:31Z","timestamp":1745465611000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000083513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000083513","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}