{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:52:00Z","timestamp":1773150720856,"version":"3.50.1"},"reference-count":69,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>The evidence supporting the important role of &lt;i&gt;Helicobacter pylori&lt;\/i&gt; causing gastric cancer is getting stronger. The mechanisms by which &lt;i&gt;H. pylori&lt;\/i&gt; can influence the progression to severe changes in the gastric mucosa are under investigation. An increased gastric epithelial cell proliferation has been observed in individuals infected with &lt;i&gt;H. pylori&lt;\/i&gt;. This lifelong increased cell turnover is deemed to be a major risk factor for increased mutational changes and may lead to the development of gastric cancer. Successful eradication of &lt;i&gt;H. pylori&lt;\/i&gt; infection induces the healing of the gastritis and a significant decrease in gastric epithelial cell proliferation. Nevertheless, it is right now unknown at which time the point of no return, meaning at which time an eradication therapy leads to a benefit for the individual to prevent gastric cancer, has been reached. Therefore the major question that arises is to whom an eradication therapy should be offered to prevent gastric cancer. A general elimination of the infection might be worthwhile, but seems to be unrealistic now because of the high prevalence of the infection and the missing of a vaccine. This review reflects possible mechanisms of gastric cancer development induced by chronic &lt;i&gt;H. pylori&lt;\/i&gt; infection and recent investigational trials for prevention of gastric cancer by &lt;i&gt;H. pylori&lt;\/i&gt; eradication therapy will be discussed.<\/jats:p>","DOI":"10.1159\/000083592","type":"journal-article","created":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T08:14:07Z","timestamp":1112343247000},"page":"313-319","source":"Crossref","is-referenced-by-count":8,"title":["Prevention of Gastric Cancer by &lt;i&gt;Helicobacter pylori 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