{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:47:53Z","timestamp":1760622473609,"version":"3.40.4"},"reference-count":3,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>In this double-blind, placebo-controlled, crossover study we compared the bronchoprotective effects of formoterol 12 \u00b5g inhaled via an HFA-134a inhaler (Modulite&lt;sup&gt;\u00ae&lt;\/sup&gt; HFA) versus a CFC and a DPI device in 38 patients with mild-to-moderate persistent asthma. All three formoterol preparations significantly increased methacholine PD&lt;sub&gt;20 &lt;\/sub&gt;and FEV&lt;sub&gt;1 &lt;\/sub&gt;and improved small airway function parameters compared with placebo (p &lt; 0.001). No significant differences were observed between formoterol formulations. In conclusion, Modulite&lt;sup&gt;\u00ae&lt;\/sup&gt; HFA formoterol was found to be an effective and well tolerated treatment in patients with asthma, with comparable efficacy to current formoterol preparations.<\/jats:p>","DOI":"10.1159\/000083691","type":"journal-article","created":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T12:39:02Z","timestamp":1116851942000},"page":"35-37","source":"Crossref","is-referenced-by-count":5,"title":["Bronchoprotective and Bronchodilator Effects of an HFA pMDI vs. a CFC pMDI and a DPI Containing Formoterol in Asthma Patients"],"prefix":"10.1159","volume":"72","author":[{"given":"S.J.","family":"Langley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Houghton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.D.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0954-6111%2802%2980018-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006%2Fpupt.2001.0310"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.121409"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:35:45Z","timestamp":1745465745000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000083691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":3,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000083691","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2005]]}}}