{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:12:57Z","timestamp":1761822777609,"version":"3.40.4"},"reference-count":3,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To report a case of glucocorticoid substitution in panhypopituitarism that can lead to uncontrolled rise in serum sodium and myelinolysis. &lt;i&gt;Clinical Presentation and Intervention:&lt;\/i&gt; A 42-year-old man presented with disturbed conscious level and hyponatremia. Initial data suggested glucocorticoid deficiency. Later, hormonal levels indicated panhypopituitarism. MRI of the brain led to the diagnosis of a pituitary macroadenoma. Glucocorticoid substitution was initiated immediately after admission, and possible myelinolysis subsequently became a complication. We report this case to illustrate the fact that glucocorticoid substitution can lead to rapid rise in serum sodium and myelinolysis in panhypopituitarism. &lt;i&gt;Conclusion:&lt;\/i&gt; This case illustrated the need to use minimum doses of glucocortcoids with close monitoring of serum sodium, in order to avoid this complication.<\/jats:p>","DOI":"10.1159\/000083923","type":"journal-article","created":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T13:08:08Z","timestamp":1111583288000},"page":"115-117","source":"Crossref","is-referenced-by-count":13,"title":["Glucocorticoid Replacement in Panhypopituitarism Complicated by Myelinolysis"],"prefix":"10.1159","volume":"14","author":[{"given":"Ibrahim","family":"Lasheen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail A.R.","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal A.S.","family":"Al-Shoumer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.80.7.2190"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F102.2.361"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-9260%2805%2981191-2"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/83923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:37:45Z","timestamp":1745465865000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000083923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":3,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000083923","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2005]]}}}