{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:28:01Z","timestamp":1776702481988,"version":"3.51.2"},"reference-count":45,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Evidence suggests that recombinant human erythropoietin (rHuEPO) protects neurons and cardiomyocytes from acute insults. We investigated the protective effect of rHuEPO on cyclosporine (CsA)-induced renal injury. &lt;i&gt;Methods:&lt;\/i&gt; CsA (15 mg\/kg\/day) was given to rats for 1 or 4 weeks, and rHuEPO was concurrently administered at a dose of 100 units\/kg (thrice weekly). Effects of rHuEPO on CsA-induced renal injury were evaluated with tubulointerstitial fibrosis (TIF) score, macrophage infiltration, expression of proinflammatory and profibrotic cytokines, and apoptotic cell death. &lt;i&gt;Results:&lt;\/i&gt; Administration of rHuEPO decreased TIF score and the number of macrophages, which increased significantly in CsA-treated rat kidneys. At the molecular level, rHuEPO treatment decreased proinflammatory mediators (osteopontin and C-reactive protein) and profibrotic mediators (transforming growth factor-\u03b21 and transforming growth factor-\u03b21-inducible gene-h3). Increased apoptotic cell death in CsA-treated rat kidneys was significantly decreased with rHuEPO cotreatment, and apoptosis-related genes were regulated in favor of cell survival (increased Bcl-2 and suppressed caspase-3). &lt;i&gt;Conclusion:&lt;\/i&gt; rHuEPO has a renoprotective effect against chronic CsA-induced renal injury.<\/jats:p>","DOI":"10.1159\/000084275","type":"journal-article","created":{"date-parts":[[2005,3,3]],"date-time":"2005-03-03T11:09:56Z","timestamp":1109848196000},"page":"64-76","source":"Crossref","is-referenced-by-count":43,"title":["Attenuation of Interstitial Inflammation and Fibrosis by Recombinant Human Erythropoietin in Chronic Cyclosporine Nephropathy"],"prefix":"10.1159","volume":"25","author":[{"given":"Seung Hun","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Woo","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Ohk","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bum Soon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Sung","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Kee","family":"Bang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Woo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199803150-00010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1988.38"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.060003847.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000020664"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000020504"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-2143%2898%2990078-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-200005270-00033"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1996.165"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1995.312"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2F35088074"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0630444100"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200318200"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2802%2903239-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.051606598"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.19.10526"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.042693799"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.142287899"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.082097299"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4522%2896%2900306-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F16.5.932"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg547"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.02-0654rev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00751.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159%2F000063299"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00309.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lab.2003.10.014"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159%2F000081793"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002%2Fimmu.200390018"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2567.2003.01681.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00428.2002"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.171.6.1931"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1994.67"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1998.00748.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00408.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-200112150-00019"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20021067"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1998.00835.x"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-6143.2002.20501.x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1067%2Fmlc.2002.124397"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F16.5.932"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000070079.54912.B6"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-3782%2898%2900030-9"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199002000-00041"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1159%2F000107325"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000045034.48833.51"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:41:46Z","timestamp":1745466106000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000084275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000084275","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}