{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:54:48Z","timestamp":1782269688169,"version":"3.54.5"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Chronic intestinal pseudo-obstruction can occur as a paraneoplastic disorder, and several cases have been reported in association with thymoma or small-cell lung cancer. Autoantibodies against voltage-gated potassium channels (VGKCs) are found in acquiredneuromyotonia (Isaac\u2019s syndrome), and have been reported in one case of slow transit constipation without apparent neurological disease. We describe a patient with VGKC antibodies, acquired neuromyotonia and thymoma, who first presented with a severe slow-transit constipation and in whom the gastrointestinal symptoms responded well to plasmapheresis. We suggest that VGKC antibodies might be helpful in patients with possible paraneoplastic chronic intestinal pseudo-obstruction, and a positive result should stimulate the search for a thymoma or other tumour and raise the possibility of immunotherapy.<\/jats:p>","DOI":"10.1159\/000084300","type":"journal-article","created":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T10:14:42Z","timestamp":1110536082000},"page":"60-63","source":"Crossref","is-referenced-by-count":35,"title":["Thymoma-Associated Neuromyotonia with Antibodies against Voltage-Gated Potassium Channels Presenting as Chronic Intestinal Pseudo-Obstruction"],"prefix":"10.1159","volume":"53","author":[{"given":"Jean-Fran\u00e7ois","family":"Viallard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Parrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Pellegrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Ellie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1568-9972%2802%2900146-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410380505"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080%2F003655202753416821"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0889-8553%2803%2900028-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.61.1.44"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawf178"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2899%2900302-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109%2F00365529609094758"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2002.36600"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200009213431204"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00868410"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F124.12.2417"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10556"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200317429"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:41:58Z","timestamp":1745466118000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000084300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000084300","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}