{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:53:47Z","timestamp":1756461227216,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Objectives:<\/i> To investigate whether coexistence of high-grade prostatic intraepithelial neoplasia (HPIN) should change our therapeutic approach to infravesical obstruction. <i>Material and Methods:<\/i> Of 505 patients who underwent sextant transrectal ultrasonography (TRUS)-guided prostate biopsy, 65 (12.8%) had HPIN and 29 of them underwent prostatectomy (23 transurethral resection of prostate (TURP), 6 open) due to obstructive urinary symptoms. Patients without carcinoma were followed up with semiannual prostate-specific antigen (PSA) and digital rectal examination. After a follow-up of 24.8 \u00b1 11.0 months, 19 of 29 patients who accepted our call had another sextant biopsy. <i>Results:<\/i> Mean age and initial mean PSA values of 29 patients were 67.6 \u00b1 6.7 years and 9.26 \u00b1 5.91 ng\/ml, respectively. The final pathological evaluation of the surgical specimens revealed 2 prostatic adenocarcinomas both in the TURP group. The remaining 27 (93.2%) patients were found to have benign prostatic hyperplasia (BPH) and their serum PSA levels declined from 9.26 \u00b1 5.91 to 4.59 \u00b1 2.0 ng\/ml 3 months after prostatectomy. Of the 19 patients who had another biopsy with a mean PSA value of 4.06 \u00b1 4.61 ng\/ml, 15 and 4 of them had BPH and HPIN respectively. <i>Conclusions:<\/i> Our preliminary data indicate that the presence of HPIN on TRUS-guided biopsies is not a factor to delay an indicated surgical intervention for infravesical obstruction.<\/jats:p>","DOI":"10.1159\/000084433","type":"journal-article","created":{"date-parts":[[2005,5,13]],"date-time":"2005-05-13T11:00:16Z","timestamp":1115982016000},"page":"332-336","source":"Crossref","is-referenced-by-count":2,"title":["Should High-Grade Prostatic Intraepithelial Neoplasia Change Our Approach to Infravesical Obstruction?"],"prefix":"10.1159","volume":"74","author":[{"given":"Murat","family":"Tunc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oner","family":"Sanli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engin","family":"Kandirali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Tefekli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayfun","family":"Oktar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik","family":"Esen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Acar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli","family":"Uysal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0046-8177%2886%2980156-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2805%2980067-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0094-0143%2802%2900189-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819990101%2985%3A1%3C145%3A%3AAID-CNCR20%3E3.0.CO%3B2-Y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000049758"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199707000-00004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199609000-00058"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199510000-00004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2896%2900004-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410x.2001.02295.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819960515%2977%3A10%3C2103%3A%3AAID-CNCR21%3E3.0.CO%3B2-Y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080%2F003655900750169266"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2897%2900249-5"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:42:51Z","timestamp":1745466171000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000084433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000084433","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2005]]}}}