{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:36:39Z","timestamp":1790940999579,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,3,18]],"date-time":"2005-03-18T00:00:00Z","timestamp":1111104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,3,18]],"date-time":"2005-03-18T00:00:00Z","timestamp":1111104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; Among various kidney disease models, there are few rat glomerulonephritis (GN) models that develop in a short time, and with mainly glomerular lesions. Hypoxia-inducible factor (HIF)-1\u03b1 is a transcriptional factor that induces genes supporting cell survival, but the involvement of HIF-1\u03b1 in attenuating the progression of GN remains to be elucidated. We developed a new model of rat GN by coadministration of angiotensin II (AII) with Habu snake venom (HV) and investigated whether HIF-1\u03b1 is involved in renal protection. &lt;i&gt;Methods:&lt;\/i&gt; Male Wistar rats were unilaterally nephrectomized on day 1, and divided into 4 groups on day 0; N group (no treatment), HV group, A group (AII), and H+A group (HV and AII). To preinduce HIF-1\u03b1, cobalt chloride (CoCl&lt;sub&gt;2&lt;\/sub&gt;) was injected twice before injections of HV and AII in 11 rats. &lt;i&gt;Results:&lt;\/i&gt; GN was detected only in the H+A group; observed first on day 2 and aggravated thereafter. HIF-1\u03b1 was expressed in the glomeruli and renal tubules in the A and H+A groups. In the H+A group, GN was remarkably reduced by CoCl&lt;sub&gt;2&lt;\/sub&gt; pretreatment (44.9 to 12.2%, p &lt; 0.01). &lt;i&gt;Conclusion:&lt;\/i&gt; Both HV and AII were critical for the development of GN, and HIF-1\u03b1 remarkably attenuated the progression of GN.<\/jats:p>","DOI":"10.1159\/000084575","type":"journal-article","created":{"date-parts":[[2005,3,18]],"date-time":"2005-03-18T13:06:18Z","timestamp":1111151178000},"page":"e95-e103","source":"Crossref","is-referenced-by-count":19,"title":["Hypoxia-Inducible Factor-1\u03b1 Is Involved in the Attenuation of Experimentally Induced Rat Glomerulonephritis"],"prefix":"10.1159","volume":"100","author":[{"given":"Yoshihiro","family":"Kudo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Kakinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasukiyo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihito","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Karashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsuo","family":"Furihata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Shuin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.150.5.1161"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02732050"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000107325"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118143"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.271.50.32253"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.92.12.5510"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000017223.49823.2A"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1996.0845"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.275.13.9186"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M209114200"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1984.147"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.055003945.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1827.2003.01507.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semnephrol.2003.11.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.055003877.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2F35107085"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F91.2.106"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2F20459"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M107689200"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-200205000-00003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.193.9.1027"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000074239.22357.06"}],"container-title":["Nephron Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:43:24Z","timestamp":1745466204000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000084575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,18]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000084575","archive":["Portico"],"relation":{},"ISSN":["1660-2129"],"issn-type":[{"value":"1660-2129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,18]]}}}