{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T08:49:24Z","timestamp":1742633364493},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1159\/000084829","type":"journal-article","created":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T08:14:07Z","timestamp":1112343247000},"page":"75-80","source":"Crossref","is-referenced-by-count":5,"title":["Transforming growth factor-beta-1 variants are not associated with chronic nonalcoholic pancreatitis"],"prefix":"10.1016","volume":"5","author":[{"given":"Kerstin","family":"B\u00f6hm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Teich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Hoffmeister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"M\u00f6ssner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Keim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"B\u00f6deker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Gress","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1159\/000084829_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01605976","article-title":"The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis","volume":"420","author":"Kl\u00f6ppel","year":"1992","journal-title":"Virchows Archiv"},{"key":"10.1159\/000084829_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2739\/kurumemedj.37.67","article-title":"The vitamin A-storing cells in human and rat pancreas","volume":"37","author":"Ikejiri","year":"1990","journal-title":"Kurume Med J"},{"key":"10.1159\/000084829_bib3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/gut.43.1.128","article-title":"Periacinar stellate shaped cells in rat pancreas: Identification, isolation, and culture","volume":"43","author":"Apte","year":"1998","journal-title":"Gut"},{"key":"10.1159\/000084829_bib4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0016-5085(98)70209-4","article-title":"Identification, culture, and characterization of pancreatic stellate cells in rats and humans","volume":"115","author":"Bachem","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1159\/000084829_bib5","doi-asserted-by":"crossref","first-page":"C532","DOI":"10.1152\/ajpcell.2001.281.2.C532","article-title":"Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells","volume":"281","author":"Schneider","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1159\/000084829_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/labinvest.3780007","article-title":"Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: Implicatiions in pathogenesis of pancreatic fibrosis","volume":"80","author":"Luttenberger","year":"2000","journal-title":"Lab Invest"},{"key":"10.1159\/000084829_bib7","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0002-9440(10)65211-X","article-title":"Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis","volume":"155","author":"Haber","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1159\/000084829_bib8","first-page":"42","article-title":"Accumulation of extracellular matrix and developmental dys-regulation in the pancreas by transgenic production of transforming growth factor-\u03b2 1","volume":"147","author":"Lee","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1159\/000084829_bib9","doi-asserted-by":"crossref","first-page":"G164","DOI":"10.1152\/ajpgi.2001.280.1.G164","article-title":"Effects of fibrogenetic mediators on the development of pancreatic fibrosis in a TGF-\u03b2 1 transgenic mouse model","volume":"280","author":"Vogelmann","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1159\/000084829_bib10","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/S0002-9440(10)61125-X","article-title":"Expression of transforming-growth-factor-\u03b2 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis","volume":"160","author":"Shek","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1159\/000084829_bib11","first-page":"A414","article-title":"An antisense oligonucleotide binding to the promoter region of the TGF\u03b21 gene reduces autocrine stimulated collagen type I synthesis of cultured pancreatic stellate cells","volume":"19","author":"Bachem","year":"1999","journal-title":"Pancreas"},{"key":"10.1159\/000084829_bib12","first-page":"G4816","article-title":"Transforming-growth-factor-\u03b21 is involved in autocrine stimulated matrix synthesis of pancreatic stellate cells","volume":"116","author":"Kandenwein","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1159\/000084829_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00006676-198701000-00010","article-title":"Pancreatic extracellular alterations in chronic pancreatitis","volume":"2","author":"Kennedy","year":"1987","journal-title":"Pancreas"},{"key":"10.1159\/000084829_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00006676-200103000-00013","article-title":"Increased transforming growth factor-\u03b2 in pure pancreatic juice in pancreatitis","volume":"22","author":"Kazbay","year":"2000","journal-title":"Pancreas"},{"key":"10.1159\/000084829_bib15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1385\/IJGC:31:1-3:41","article-title":"TGF-\u03b2 1 induced fibrogenesis of the pancreas","volume":"31","author":"Menke","year":"2002","journal-title":"Int J Gastrointest Cancer"},{"key":"10.1159\/000084829_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/hmg\/8.1.93","article-title":"Genetic control of the circulating concentrations of transforming growth factor type \u03b2 1","volume":"8","author":"Grainger","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1159\/000084829_bib17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/358331a0","article-title":"Retinoblastoma gene product activates expression of the human TGF-\u03b22 gene through transcription factor ATF-3","volume":"358","author":"Kim","year":"1992","journal-title":"Nature"},{"key":"10.1159\/000084829_bib18","series-title":"The Endothelium in Clinical Practice. Source and Traget of Novel Therapies","first-page":"203","article-title":"Transforming growth factor-\u03b2 and cardiovascular protection","author":"Grainger","year":"1997"},{"key":"10.1159\/000084829_bib19","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.2646712","article-title":"Unity in function in the absence of consensus in sequence: Role of leader peptides in export","volume":"243","author":"Randall","year":"1989","journal-title":"Science"},{"key":"10.1159\/000084829_bib20","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1161\/01.CIR.101.24.2783","article-title":"Association of a T29\u2192C polymorphism of the transforming growth factor-\u03b21 gene with genetic susceptibility to myocardial infarction in Japanese","volume":"101","author":"Yokota","year":"2000","journal-title":"Circulation"},{"key":"10.1159\/000084829_bib21","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00007890-199810270-00009","article-title":"Genotypic variation in the transforming growth factor \u03b21 production, fibrotic lung disease and graft fibrosis after lung transplantation","volume":"66","author":"Awad","year":"1998","journal-title":"Transplantation"},{"key":"10.1159\/000084829_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng1096-141","article-title":"Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene","volume":"14","author":"Whitcomb","year":"1996","journal-title":"Nat Genet"},{"key":"10.1159\/000084829_bib23","first-page":"341","article-title":"Mutational screening of patients with nonalcoholic chronic pancreatitis: Identification of further trypsinogen variants","volume":"97","author":"Teich","year":"2002","journal-title":"Am Gastroenterol"},{"key":"10.1159\/000084829_bib24","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What's wrong with Bonferroni adjustments","volume":"316","author":"Perneger","year":"1998","journal-title":"BMJ"},{"key":"10.1159\/000084829_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1098-1004(1998)12:1<39::AID-HUMU6>3.0.CO;2-P","article-title":"Mutations of the cationic trypsinogen in hereditary pancreatitis","volume":"12","author":"Teich","year":"1998","journal-title":"Human Mutat"},{"key":"10.1159\/000084829_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/76088","article-title":"Mutations in the gene encoding the serine protease inhibitor Kazal type 1 are associated with chronic pancreatitis","volume":"25","author":"Witt","year":"2000","journal-title":"Nat Genet"},{"key":"10.1159\/000084829_bib27","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1001\/jama.285.21.2716-a","article-title":"Mutation in the SPINK1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis","volume":"285","author":"Witt","year":"2001","journal-title":"JAMA"},{"key":"10.1159\/000084829_bib28","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/jmg.39.5.347","article-title":"Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI\/ SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis","volume":"39","author":"Chandak","year":"2002","journal-title":"J Med Genet"},{"key":"10.1159\/000084829_bib29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/gut.50.4.535","article-title":"Pancreatic stellate cells respond to inflammatory cytokines: Potential role in chronic pancreatitis","volume":"50","author":"Mews","year":"2002","journal-title":"Gut"},{"key":"10.1159\/000084829_bib30","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1023\/A:1005423122127","article-title":"Repetitive self-limited acute pancreatitis induces pancreatic fi-brogenesis in the mouse","volume":"45","author":"Neuschwander-Tetri","year":"2000","journal-title":"Dig Dis Sci"},{"key":"10.1159\/000084829_bib31","first-page":"2610","article-title":"A transforming-growth-factor-\u03b21 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer","volume":"63","author":"Dunning","year":"2003","journal-title":"Cancer Res"},{"key":"10.1159\/000084829_bib32","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1046\/j.1365-2133.2002.04947.x","article-title":"The polymorphism of transforming growth factor \u03b21 gene in Japanese patients with systemic sclerosis","volume":"147","author":"Ohtsuka","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1159\/000084829_bib33","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00439-001-0617-y","article-title":"TGF\u03b21 allele association with asthma severity","volume":"109","author":"Pulleyn","year":"2001","journal-title":"Hum Genet"},{"key":"10.1159\/000084829_bib34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/thorax.55.6.459","article-title":"TGF-\u03b21 genotype and accelerated decline in lung function in patients with cystic fibrosis","volume":"55","author":"Arkwright","year":"2000","journal-title":"Thorax"},{"key":"10.1159\/000084829_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0009-8981(01)00738-0","article-title":"Association of polymorphisms of the transforming-growth-factor-\u03b21 gene with the rate of progression of HCV-induced liver fibrosis","volume":"316","author":"Gewaltig","year":"2002","journal-title":"Clin Chim Acta"},{"key":"10.1159\/000084829_bib36","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1161\/01.HYP.28.5.881","article-title":"Polymorphisms of the transforming growth factor-\u03b2 1 gene in relation to myocardial infarction and blood pressure (Etude Cas-T\u00e9moin de l'Infarctus du Myocarde (ECTIM) Study)","volume":"28","author":"Cambien","year":"1996","journal-title":"Hypertension"},{"key":"10.1159\/000084829_bib37","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1042\/CS19980154","article-title":"Transforming growth factor-\u03b2 1 gene polymorphisms and coronary artery disease","volume":"95","author":"Syrris","year":"1998","journal-title":"Clin Sci"},{"key":"10.1159\/000084829_bib38","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1159\/000007567","article-title":"Role of extracellular matrix in pancreatic diseases","volume":"59","author":"Gress","year":"1998","journal-title":"Digestion"},{"key":"10.1159\/000084829_bib39","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-beta signal transduction","volume":"67","author":"Massague","year":"1998","journal-title":"Annu Rev Biochem."},{"key":"10.1159\/000084829_bib40","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of TGF\u03b2 in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1159\/000084829_bib41","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00007890-199810270-00009","article-title":"Genotypic variation in the transforming growth factor-\u03b2 1 gene: Association with transforming growth factor-\u03b2 1 production, fibrotic lung disease, and graft fibrosis after lung transplantation","volume":"66","author":"Awad","year":"1998","journal-title":"Transplantation"},{"key":"10.1159\/000084829_bib42","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","article-title":"The International HapMap Project","volume":"426","year":"2003","journal-title":"Nature"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390305800407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390305800407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T06:17:42Z","timestamp":1549606662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390305800407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S1424390305800407"],"URL":"https:\/\/doi.org\/10.1159\/000084829","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}