{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:27Z","timestamp":1747183887053,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Background:<\/i> Postnatal alterations in pulmonary mechanics, energetics and functional residual capacity (FRC) describe the structural maturation of the preterm respiratory system. <i>Objective:<\/i> To evaluate longitudinal changes in pulmonary function in infants with respiratory distress syndrome (RDS) treated with oxygen, positive pressure ventilation and synthetic surfactant (Exosurf<sup>\u00ae<\/sup>). <i>Methods:<\/i> Serial pulmonary function tests were performed in surfactant-treated infants [mean \u00b1 SD birth weight (BW) = 1,112 \u00b1 276 g, gestational age (GA) = 29 \u00b1 3 weeks] at postnatal ages: <3 days, 1, 2, 3, 4 and 6\u20138 weeks until term postmenstrual age (PMA). Tidal volume, pulmonary compliance (C<sub>L<\/sub>), pulmonary resistance (R<sub>T<\/sub>) and flow-resistive work were analyzed following simultaneous measurements of airflow and transpulmonary pressure signals. Serial FRC measurements were made in a randomly selected group. <i>Results:<\/i> Prior to 28 weeks\u2019 PMA, C<sub>L<\/sub> was unchanged irrespective of GA. At age 1 week the likelihood ratio (LR) for bronchopulmonary dysplasia (BPD) based on C<sub>L<\/sub>, R<sub>T<\/sub> and GA was predicted to be >90% for those with BW <750 g (LR >100) as compared to <10% probability (LR = 0.3) for infants >1,500 g. Significant linear increase in C<sub>L<\/sub> to PMA was evident >28 weeks\u2019 PMA (r = 0.86, p < 0.01) at 0.17 ml\/cm H<sub>2<\/sub>O\/kg\/week. By term PMA, mean C<sub>L<\/sub> was 2.60 \u00b1 0.07 ml\/cm H<sub>2<\/sub>O. Improvements in FRC of preterm infants with RDS who recovered occur at a more rapid rate (\u223c25 ml\/kg) compared to those who developed BPD (\u223c20 ml\/kg). <i>Conclusions:<\/i> Slow but incremental postnatal pulmonary improvement, minimal <28 weeks\u2019 PMA, were comparable for all infants. Along with diminished FRC, these changes reflect persistent deleterious effects of positive pressure ventilation, alveolar hyperoxia and unrecognized pulmonary overdistension.<\/jats:p>","DOI":"10.1159\/000084880","type":"journal-article","created":{"date-parts":[[2005,6,24]],"date-time":"2005-06-24T08:57:06Z","timestamp":1119603426000},"page":"323-331","source":"Crossref","is-referenced-by-count":14,"title":["Postnatal Changes in Pulmonary Mechanics and Energetics of Infants with Respiratory Distress Syndrome following Surfactant Treatment"],"prefix":"10.1159","volume":"87","author":[{"given":"Vinod K.","family":"Bhutani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank W.","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emidio M.","family":"Sivieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2880%2990489-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198808253190804"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.1950050104"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2982057-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199310000-00022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-198704000-00001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.1950040306"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2982491-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2886%2980296-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2887%2980516-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2001.118201"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053%2Fsiny.2002.0133"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199112123252404"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.1950170303"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2806%2980021-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2981228-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2888%2980391-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.1950080206"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-198607000-00018"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F00008480-200104000-00006"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.physiol.62.1.825"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F00000542-200407000-00002"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F01.CCM.0000148231.04642.8D"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097%2F00000542-200407000-00010"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200310-1417OC"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:46:23Z","timestamp":1745466383000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000084880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000084880","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2005]]}}}