{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:26:11Z","timestamp":1775744771297,"version":"3.50.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Pfeiffer syndrome is an extremely rare autosomal-dominant condition whose prenatal diagnosis has only been reported 6 times, mainly on the basis of a fetal cloverleaf skull deformity. Three types have been described, each with a different prognosis. This case report stresses the need to thoroughly analyze the fetus and particularly the fetal hands in case of prenatal observation of a cloverleaf skull. The discovery of characteristic hand abnormalities allowed the early prenatal detection of type 2 Pfeiffer syndrome in our patient.<\/jats:p>","DOI":"10.1159\/000085089","type":"journal-article","created":{"date-parts":[[2005,6,24]],"date-time":"2005-06-24T08:57:06Z","timestamp":1119603426000},"page":"296-300","source":"Crossref","is-referenced-by-count":15,"title":["Prenatal Diagnosis of Cloverleaf Skull: Watch the Hands!"],"prefix":"10.1159","volume":"20","author":[{"given":"Guillaume","family":"Gorincour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Rypens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9e","family":"Grignon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Garel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Bortoluzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Oligny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Lemyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Duperron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00447500"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.1320450616"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1970010209"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1970140108"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1997.08060425.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.2000.00178.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00019605-199701000-00016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.91"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01660748"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00006534-199607000-00004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1970151220"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0030-6665%2805%2970280-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000020881"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.230"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1998.12040227.x"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:49:03Z","timestamp":1745466543000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000085089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000085089","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}