{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:50:20Z","timestamp":1761540620582,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Hered"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>On extended pedigrees with extensive missing data, the calculation of multilocus likelihoods for linkage analysis is often beyond the computational bounds of exact methods. Growing interest therefore surrounds the implementation of Monte Carlo estimation methods. In this paper, we demonstrate the speed and accuracy of a new Markov chain Monte Carlo method for the estimation of linkage likelihoods through an analysis of real data from a study of early-onset Alzheimer\u2019s disease. For those data sets where comparison with exact analysis is possible, we achieved up to a 100-fold increase in speed. Our approach is implemented in the program lm\u2013bayes within the framework of the freely available MORGAN 2.6 package for Monte Carlo genetic analysis (http:\/\/www.stat.washington.edu\/thompson\/Genepi\/MORGAN\/Morgan.shtml).<\/jats:p>","DOI":"10.1159\/000085224","type":"journal-article","created":{"date-parts":[[2005,4,20]],"date-time":"2005-04-20T09:32:28Z","timestamp":1113989548000},"page":"98-108","source":"Crossref","is-referenced-by-count":13,"title":["MCMC Multilocus Lod Scores: Application of a New Approach"],"prefix":"10.1159","volume":"59","author":[{"given":"Andrew W.","family":"George","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen M.","family":"Wijsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.81.11.3443"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-402"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000152448"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2307%2F1426718"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.84.8.2363"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0010-4809%2885%2990004-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1411576"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1086%2F319507"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fng786"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2307%2F2334940"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1109%2FTPAMI.1984.4767596"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1751-5823.2000.tb00387.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2307%2F2532855"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fimammb%2F8.3.149"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1214%2Fss%2F1081443233"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2307%2F2291325"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.7638621"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2307%2F2289776"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.7638622"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410230106"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410250104"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159%2F000154222"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1214%2Fss%2F1177010381"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1086%2F515506"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2307%2F2291224"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008947712763"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-1809.1994.tb00731.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.2307%2F2532611"}],"container-title":["Human Heredity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:49:55Z","timestamp":1745466595000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000085224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000085224","archive":["Portico"],"relation":{},"ISSN":["0001-5652","1423-0062"],"issn-type":[{"type":"print","value":"0001-5652"},{"type":"electronic","value":"1423-0062"}],"subject":[],"published":{"date-parts":[[2005]]}}}