{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:56:23Z","timestamp":1792000583389,"version":"4.4.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T00:00:00Z","timestamp":1114128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T00:00:00Z","timestamp":1114128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background and Objectives:&lt;\/i&gt; Oxysterols are markers of oxidative stress, levels of which have not yet been reported in hemodialysis (HD) patients. This study was designed to compare levels of the oxysterols 7-ketocholesterol (7KC) and 7\u03b2-hydroxycholesterol (7\u03b2OH) between a cohort of HD patients and healthy controls. &lt;i&gt;Methods:&lt;\/i&gt; This nested cross-sectional study reflects baseline (pre-intervention) values for markers of oxidative stress, inflammation and nutrition status in the 160-member vitamin E and carotid intima media thickness progression in end-stage renal disease (VIPER) cohort (age 64.1 \u00b1 8.8, 33.5% female). Age- and sex-matched healthy volunteers served as controls. Plasma oxysterols 7KC and 7\u03b2OH were determined by isotope dilution gas chromatography\/mass spectrometry. &lt;i&gt;Results:&lt;\/i&gt; Despite higher plasma \u03b1-tocopherol levels in HD patients than controls (36.0 \u00b1 9.3 vs. 31.8 \u00b1 8.4 \u00b5mol\/l, p = 0.007), 7KC levels (9.8 \u00b1 6.9 vs. 5.9 \u00b1 2.8 nmol\/mmol cholesterol, p &lt; 0.0001) and 7\u03b2OH levels (8.7 \u00b1 4.3 vs. 2.7 \u00b1 1.6 nmol\/mmol cholesterol, p &lt; 0.0001) were higher in HD patients. The oxysterol 7\u03b2OH was significantly, inversely associated with prealbumin (r = \u20130.18, p = 0.03), though neither oxysterol was significantly associated with any other marker of oxidative stress, inflammation or nutrition status and did not discriminate for CVD in HD patients. &lt;i&gt;Conclusions:&lt;\/i&gt; Elevated levels of the oxysterols 7KC and 7\u03b2OH indicate that HD patients are in a state of oxidative stress compared to healthy controls. However, oxysterols 7KC and 7\u03b2OH did not appear to contribute additional information about oxidative stress among HD patients.<\/jats:p>","DOI":"10.1159\/000085290","type":"journal-article","created":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T06:35:19Z","timestamp":1114151719000},"page":"c111-c119","source":"Crossref","is-referenced-by-count":15,"title":["Baseline Oxysterols and Other Markers of Oxidative Stress, Inflammation and Malnutrition in the Vitamin E and Intima Media Thickness Progression in End-Stage Renal Disease (VIPER) 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