{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:26:39Z","timestamp":1779359199655,"version":"3.51.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Taxanes cause hypersensitivity reactions, averted by premedication with H&lt;sub&gt;1&lt;\/sub&gt; blockers and high glucocorticoid (GC) doses. Prolonged weekly taxane administration may lead to GC toxicity. &lt;i&gt;Purpose:&lt;\/i&gt; To determine whether patients not hypersensitive to initial paclitaxel (PTX) infusion after high-dose GC premedication will tolerate subsequent, prolonged PTX treatment without GC prophylaxis. &lt;i&gt;Patients and Methods:&lt;\/i&gt; In 115\/122 breast cancer patients not hypersensitive to initial PTX treatment, 20 mg dexamethasone (DXM) doses were tapered by 2.0 mg\/week, reaching 0 in those receiving 9 or more courses. After 4 PTX courses, diphenhydramine was administered orally, rather than intravenously. &lt;i&gt;Results:&lt;\/i&gt; PTX was administered 143 times after 2.0\u20135.0 mg of DXM and 357 times without DXM. A total of 46 patients received 1\u201340 PTX courses without DXM. None of these 115 patients experienced hypersensitivity reactions. &lt;i&gt;Conclusion:&lt;\/i&gt; Patients unreactive to their first PTX infusions, after high-dose and tapering GC premedication, may not require GC prophylaxis for subsequent PTX therapy.<\/jats:p>","DOI":"10.1159\/000085618","type":"journal-article","created":{"date-parts":[[2005,5,11]],"date-time":"2005-05-11T13:28:20Z","timestamp":1115818100000},"page":"116-119","source":"Crossref","is-referenced-by-count":14,"title":["Tapering and Discontinuation of Glucocorticoid Prophylaxis during Prolonged Weekly to Biweekly Paclitaxel Administration"],"prefix":"10.1159","volume":"51","author":[{"given":"Albert S.","family":"Braverman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujatha","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ellen","family":"Salvatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Adamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"McManus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Pierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F88.7.463"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008207025430"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.1998.4993"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004320050297"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.2001.6331"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.2001.6546"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1081%2FCNV-120003535"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.12.109"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2896%2970281-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.02.063"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:53:24Z","timestamp":1745466804000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000085618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":10,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000085618","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}