{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:05:29Z","timestamp":1778663129126,"version":"3.51.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To investigate a potential relationship between I\/D polymorphism within intron 16 of the angiotensin-converting enzyme (ACE) gene located on human chromosome 17 and Beh\u00e7et\u2019s disease. &lt;i&gt;Materials and Methods:&lt;\/i&gt; Genomic DNA was obtained from 35 Turkish patients diagnosed with Beh\u00e7et\u2019s disease according to the International Study Group criteria and 150 healthy individuals. Polymerase chain reaction was used to detect the presence of I and D (insertion and deletion) alleles in intron 16 of the ACE gene in these DNA samples. &lt;i&gt;Results:&lt;\/i&gt; We found differences in ACE I\/D polymorphism between Beh\u00e7et\u2019s disease and healthy controls (\u03c7&lt;sup&gt;2&lt;\/sup&gt; = 4.61, d.f. = 1, p = 0.044). In Beh\u00e7et\u2019s disease patients, the D allele frequency was 84.3% and I allele frequency 15.7%. &lt;i&gt;Conclusion:&lt;\/i&gt; An association between Beh\u00e7et\u2019s disease and ACE polymorphism may provide a useful basis for future molecular studies and therapeutic approaches in this complex disease.<\/jats:p>","DOI":"10.1159\/000085737","type":"journal-article","created":{"date-parts":[[2005,6,17]],"date-time":"2005-06-17T09:25:35Z","timestamp":1119000335000},"page":"213-216","source":"Crossref","is-referenced-by-count":16,"title":["Angiotensin-Converting Enzyme I\/D Polymorphism in Beh\u00e7et\u2019s Disease"],"prefix":"10.1159","volume":"14","author":[{"given":"Sebahat","family":"Turgut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnfer","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erol \u00d6mer","family":"Atalay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayfer","family":"Atalay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.gene.6363863"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199910213411707"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-3083.2001.00251.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970246-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2800%2900902-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114844"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109%2F03630268208996930"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Frheumatology%2F38.12.1171"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0303-7207%2801%2900424-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-5491.1999.00071.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004410000309"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F14.2.283"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:54:37Z","timestamp":1745466877000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000085737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000085737","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}