{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:29:04Z","timestamp":1790796544949,"version":"4.1.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Background:<\/i> The optimal treatment of patients with metastatic colorectal cancer is still a clinical challenge. We describe the use of combined hepatic arterial infusion (HAI) of irinotecan (CPT-11) in conjunction with systemic chronotherapy infusion of 5-fluorouracil (5FU), folinic acid and carboplatin in patients with colorectal liver metastases. <i>Methods:<\/i> Twenty-three patients with colorectal cancer and isolated liver metastases were enrolled in this trial. Intraoperative insertion of an intra-arterial catheter into the hepatic artery was accomplished during the colon operation (in cases of synchronous tumor) or as a separate procedure in colorectal cancer patients with newly diagnosed liver metastases. A systemic double-lumen double-chamber port was inserted via the subclavian vein as a separate procedure. The treatment plan included irinotecan given by intra-arterial infusion at 150 mg\/m<sup>2<\/sup> for 1 h. After 2 weeks of rest chronomodulated 5FU (700 mg\/m<sup>2<\/sup>; peak delivery rate at 04:00 h), leucovorin (175 mg\/m<sup>2<\/sup>; peak delivery rate at 04:00 h) and carboplatin (40 mg\/m<sup>2<\/sup>; peak delivery rate at 16:00 h) for 4 days was followed by 10 days\u2019 rest and then given again. After 10 days\u2019 rest another HAI was introduced using the same method. Each cycle of therapy included 2 HAI courses and 2 chronotherapy courses in between. After 2 complete cycles, patients were evaluated for their response with weekly accessed toxicity recording. <i>Results:<\/i> Seven women, 8 men, median age 61 years (range 46\u201372). Eight patients had synchronous colon and hepatic disease and 7 patients had metachronous disease. Ten patients had previously been treated with 5FU and leucovorin while 5 patients were chemonaive. The mean number of cycles were 11.6 per patient (range 8\u201319). Partial response was achieved in 6 patients (40%) and was followed by laparoscopic radiofrequency ablation in 5 patients (33%). Disease stabilization was observed in 2 patients (13%) and disease progression in 7 patients (47%) mainly after previous chemotherapy failure. Side effects were infrequent and mild including grade 2 GIT complaints (5 patients), RUQ pain during HAI (9 patients) and grade 2 hematological complaints in 2 patients. <i>Conclusion:<\/i> A combined chemotherapy protocol (HAI and chronotherapy) with irinotecan (CPT-11) together with chronomodulated infusion of 5FU, folinic acid and carboplatin can be used in metastatic colorectal patients with a high efficacy rate and minor side effects especially in pretreated patients.<\/jats:p>","DOI":"10.1159\/000085770","type":"journal-article","created":{"date-parts":[[2005,5,11]],"date-time":"2005-05-11T13:28:20Z","timestamp":1115818100000},"page":"111-115","source":"Crossref","is-referenced-by-count":12,"title":["Combined Systemic Chronotherapy and Hepatic Artery Infusion for the Treatment of Metastatic Colorectal Cancer Confined to the Liver"],"prefix":"10.1159","volume":"51","author":[{"given":"Mordechai","family":"Shimonov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Hayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samario","family":"Chaitchik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Brener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinhas","family":"Schachter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Czerniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2820000515%2988%3A10%3C2398%3A%3AAID-CNCR26%3E3.0.CO%3B2-I"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819960815%2978%3A4%3C918%3A%3AAID-CNCR32%3E3.0.CO%3B2-W"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1711500308"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28196901%2923%3A1%3C198%3A%3AAID-CNCR2820230126%3E3.0.CO%3B2-J"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-198712000-00001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053%2Fsonc.2002.31680"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2899%2900282-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1385%2FMO%3A21%3A1%3A01"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819810101%2947%3A1%3C207%3A%3AAID-CNCR2820470134%3E3.0.CO%3B2-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819990615%2985%3A12%3C2532%3A%3AAID-CNCR7%3E3.0.CO%3B2-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200009283431302"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053%2Fsonc.2002.35524"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000071144"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000057669"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:54:57Z","timestamp":1745466897000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000085770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":14,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000085770","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}