{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:20:45Z","timestamp":1790983245991,"version":"4.1.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Aim:<\/i> To determine the molecular mechanisms underlying the efficacy of bacillus Calmette-Gu\u00e9rin (BCG) therapy against superficial carcinoma of the urinary bladder, we evaluated the expression of cytotoxic molecules on tumor-infiltrating lymphocytes before and after therapy. <i>Methods:<\/i> Immunofluorescence staining allowed the specific detection of Fas, Fas ligand (FasL), and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression on tumor cells and the respective leukocyte populations in biopsy samples from 6 patients. <i>Results:<\/i> Significant increases in the infiltration of FasL- and TRAIL-expressing CD4+ T cells and macrophages and FasL-expressing CD8+ T and NK cells were observed after BCG instillation in bladder carcinoma. Moreover, Fas expression was upregulated on tumor cells after BCG instillation. <i>Conclusion:<\/i> The data suggested that the enhanced infiltration of FasL- and\/or TRAIL-expressing leukocytes (CD4+ T cells, CD8+ T cells, natural killer cells and macrophages) and the induction of Fas expression on tumor cells may play an important role in the therapeutic effect of BCG instillation.<\/jats:p>","DOI":"10.1159\/000085934","type":"journal-article","created":{"date-parts":[[2005,7,22]],"date-time":"2005-07-22T09:57:40Z","timestamp":1122026260000},"page":"80-87","source":"Crossref","is-referenced-by-count":16,"title":["Fas Ligand and TNF-Related Apoptosis-Inducing Ligand Induction on Infiltrating Lymphocytes in Bladder Carcinoma by Bacillus Calmette-Gu\u00e9rin Treatment"],"prefix":"10.1159","volume":"75","author":[{"given":"Murat","family":"Mehmut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideko","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Fujime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199110243251703"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2388%28199709%2F10%2913%3A5%3C342%3A%3AAID-SSU8%3E3.0.CO%3B2-D"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000073852.24341.4a"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199602000-00016"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199508000-00072"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2907422-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.2002.01734.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fni1102-991"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291521-4141%28199904%2929%3A04%3C1390%3A%3AAID-IMMU1390%3E3.3.CO%3B2-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2F369031a0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.184.5.1781"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.187.11.1825"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2F83416"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20011171"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.193.6.661"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS1074-7613%2802%2900502-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2F35090591"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20012065"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819891001%2964%3A7%3C1447%3A%3AAID-CNCR2820640715%3E3.0.CO%3B2-Y"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-065X.1995.tb00684.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.166.4.1084"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.184.3.963"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI1422"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2899%2970189-7"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.189.8.1343"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2F1074-7613%2895%2990057-8"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.271.22.12687"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-04-0374"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.272.26.16351"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M100815200"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1205255"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc821"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:07:08Z","timestamp":1745464028000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000085934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000085934","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}