{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:08:58Z","timestamp":1745554138713,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Background:<\/i> Large intrathoracic airway defects may be closed using a pedicled latissimus dorsi (LD) flap, with rewarding results. This study addresses the question of whether this holds true for extrathoracic non-circumferential tracheal defects. <i>Methods:<\/i> A cervical segment of the trachea of 4 \u00d7 1 cm was resected in 9 white male pigs. The defect was stented with a silicone stent for 3 months and closed either by an LD flap alone (group a, n = 3), an LD flap with an attached rib segment covered by pleura (group b, n = 3), or an LD flap reinforced by a perforated polylactide (MacroPore<sup>\u00ae<\/sup>) plate (group c, n = 3). The trachea was assessed by rigid endoscopy at 3 and 4 months and histologically at 4 months postoperatively. <i>Results:<\/i> The degree of stenosis at the level of the reconstruction at 4 months was 25, 50 and 75% in group a, 15, 50 and 60% in group b, and 20, 95 and 95% in group c, respectively. The percentage of the defect covered by columnar epithelium was 100% in all animals of group a, 60, 100 and 100% in group b, and 10, 0 and 0% in group c. Resorption of the rib was seen in all animals of group b and obstructive inflammatory polyps were found in 2 animals of group c. <i>Conclusion:<\/i> Pedicled LD flaps provided less satisfactory results for closure of large non-circumferential extrathoracic airway defects than observed after intrathoracic reconstruction. A pedicled rib segment added to the LD flap did not improve the results obtained from LD flap repair alone, and an embedded MacroPore<sup>\u00ae<\/sup> prosthesis may result in severe airway stenosis due to plate migration and intense inflammatory reaction protruding into the tracheal lumen.<\/jats:p>","DOI":"10.1159\/000085959","type":"journal-article","created":{"date-parts":[[2005,8,4]],"date-time":"2005-08-04T14:56:49Z","timestamp":1123167409000},"page":"129-136","source":"Crossref","is-referenced-by-count":1,"title":["Repair of Non-Circumferential Cervical Trachea Defects by Three Different Latissimus Dorsi Flaps"],"prefix":"10.1159","volume":"37","author":[{"given":"D.","family":"Christoforidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pezzetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Simon-Valla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Gebhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pasche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-B.","family":"Ris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-196509000-00007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-4975%2803%2901462-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.18003815008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.40.1.32"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-195210000-00017"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800520114"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS1053-2498%2802%2900410-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-4975%2898%2900270-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS1010-7940%2897%2900180-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02470647"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85959","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:07:20Z","timestamp":1745464040000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000085959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000085959","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"type":"print","value":"0014-312X"},{"type":"electronic","value":"1421-9921"}],"subject":[],"published":{"date-parts":[[2005]]}}}