{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:22:13Z","timestamp":1791937333590,"version":"4.3.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"2-4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Interleukin (IL)-1 and IL-18 belong to the IL-1 family. IL-18 deficiency has been shown to confer moderate protection after hypoxia-ischemia (HI) in the immature brain, while the contribution of the two isoforms of IL-1 (IL-1\u03b1 and IL-1\u03b2) in neonatal HI brain injury has not been investigated previously. The aim of this study was to examine the contribution of the different members of the IL-1 family to neonatal HI damage. Unilateral HI was induced at postnatal day 9 in IL-1\u03b2, IL-1\u03b218, and IL-1\u03b1\u03b2 knockout and wild-type mice and brain injury was evaluated 1 week later. IL-1\u03b218-deficient mice showed 17% reduction in brain injury, while no significant reduction in injury was detected between any of the other groups. These results indicate that IL-18, but not IL-1\u03b2, or the combination of IL-1\u03b1 and IL-1\u03b2, is a contributor to HI injury in the immature brain.<\/jats:p>","DOI":"10.1159\/000085986","type":"journal-article","created":{"date-parts":[[2005,7,26]],"date-time":"2005-07-26T10:27:42Z","timestamp":1122373662000},"page":"143-148","source":"Crossref","is-referenced-by-count":30,"title":["Combined Deficiency of IL-1\u03b218, but Not IL-1\u03b1\u03b2, Reduces Susceptibility to Hypoxia-Ischemia in the Immature Brain"],"prefix":"10.1159","volume":"27","author":[{"given":"Maj","family":"Hedtj\u00e4rn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Mallard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hagberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,7,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2899%2900202-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199610000-00015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0361-9230%2892%2990033-T"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199609000-00017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006%2Fexnr.1994.1215"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jcbfm.9600002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2F379591a0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-200201000-00008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F01.WCB.0000059587.71206.BA"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1020506300324"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199802000-00009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199910000-00006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.187.9.1463"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS1074-7613%2800%2980543-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2898%2900892-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410090206"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199301000-00013"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199802000-00014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199806000-00005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199901000-00010"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2898%2900392-9"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199808000-00003"}],"container-title":["Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/85986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:07:34Z","timestamp":1745464054000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000085986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":22,"journal-issue":{"issue":"2-4","published-online":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000085986","archive":["Portico"],"relation":{},"ISSN":["0378-5866","1421-9859"],"issn-type":[{"value":"0378-5866","type":"print"},{"value":"1421-9859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}