{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:23:53Z","timestamp":1776741833531,"version":"3.51.2"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Background:<\/i> Patients with ischaemic stroke due to occlusion of the basilar or vertebral arteries may develop a rapid deterioration in neurological status leading to coma and often to death. While intra-arterial thrombolysis may be used in this context, no randomised controlled data exist to support its safety or efficacy. <i>Methods:<\/i> Randomised controlled trial of intra-arterial urokinase within 24 h of symptom onset in patients with stroke and angiographic evidence of posterior circulation vascular occlusion. <i>Results:<\/i> Sixteen patients were randomised, and there was some imbalance between groups, with more severe strokes occurring in the treatment arm. A good outcome was observed in 4 of 8 patients who received intra-arterial urokinase compared with 1 of 8 patients in the control group. <i>Conclusions:<\/i> These results support the need for a large-scale study to establish the efficacy of intra-arterial thrombolysis for acute basilar artery occlusion.<\/jats:p>","DOI":"10.1159\/000086121","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T07:59:50Z","timestamp":1117612790000},"page":"12-17","source":"Crossref","is-referenced-by-count":168,"title":["Results of a Multicentre, Randomised Controlled Trial of Intra-Arterial Urokinase in the Treatment of Acute Posterior Circulation Ischaemic Stroke"],"prefix":"10.1159","volume":"20","author":[{"given":"M.R.","family":"Macleod","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.P.","family":"Gerraty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.J.","family":"Hankey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.G.","family":"Stewart-Wynne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"McNeil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.F.","family":"Bladin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.R.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.K.","family":"Herkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.A.","family":"Donnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199512143332401"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.282.21.2003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000068782.15297.28"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2008-1070010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2003.020479"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000113783.45745.BE"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000108174"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000024524.71680.C6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000124126.17508.d3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177%2F1051228403261462"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.292.15.1862"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000082721.62796.09"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:09:08Z","timestamp":1745464148000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000086121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000086121","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}