{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:03:26Z","timestamp":1761487406122,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To describe the effect of reoxygenation with 100% O&lt;sub&gt;2&lt;\/sub&gt; as compared to the effect of room air in newborn rat brains after asphyxia. &lt;i&gt;Methods:&lt;\/i&gt; Experimental asphyxia (carotid artery ligation followed by hypoxic exposure with 8% O&lt;sub&gt;2&lt;\/sub&gt; for 2 h) was performed on 7-day-old rats. After hypoxia-ischemia the rats were reoxygenated with either 100% O&lt;sub&gt;2&lt;\/sub&gt; (hyperoxia group) or 21% O&lt;sub&gt;2&lt;\/sub&gt; (room air group) for 24 h and then returned to the dam. The rats were killed 1 week after the experiment to study the cerebral cortex and hippocampus. &lt;i&gt;Results:&lt;\/i&gt; Rats reoxygenated with 100% O&lt;sub&gt;2&lt;\/sub&gt; post-asphyxia showed more frequency of cortical damage (10 of 24 rats) than those reoxy genated with room air (3 of 24 rats) (\u03c7&lt;sup&gt;2&lt;\/sup&gt; test, p = 0.02). &lt;i&gt;Conclusion:&lt;\/i&gt; We consider that hyperoxia with 100% oxygen after hypoxia-ischemia can cause more damage in the cerebral cortex than room air in newborn rats.<\/jats:p>","DOI":"10.1159\/000086206","type":"journal-article","created":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T14:20:11Z","timestamp":1118154011000},"page":"168-171","source":"Crossref","is-referenced-by-count":31,"title":["Hyperoxia with 100% Oxygen following Hypoxia-Ischemia Increases Brain Damage in Newborn Rats"],"prefix":"10.1159","volume":"88","author":[{"given":"Roberto","family":"Shimabuku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Pereyra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty","family":"V\u00e9liz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Nakachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"More","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Oliveros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,9,29]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1542%2Fpeds.106.3.e29"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1586\/epr.10.105"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.2174\/156652411795976600"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1542%2Fpeds.102.1.e1"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016%2FS0140-6736%2804%2917189-4"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1159%2F000080950"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1542%2Fpeds.107.4.642"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016%2FS0140-6736%2804%2917203-6"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1159%2F000080951"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1016%2FS0002-9378%2897%2970139-X"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1016\/S0094-5765(01)00023-6"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1203%2F01.PDR.0000141988.89820.E3"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1067%2Fmpd.2003.252"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:10:12Z","timestamp":1745464212000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000086206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000086206","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2005]]}}}