{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:10:59Z","timestamp":1791411059628,"version":"4.3.3"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background\/Aims:<\/i> Fibroblast growth factor-23 (FGF-23) is a recently discovered phosphaturic factor. Although increased levels of serum FGF-23 have been reported in dialysis patients, the role of high FGF-23 levels remains unclear. Since FGF-23 is associated also with vitamin D metabolism, we examined the changes of serum FGF-23 levels in chronic dialysis patients treated with intravenous calcitriol therapy. <i>Methods:<\/i> Thirty patients with severe secondary hyperparathyroidism were treated with intravenous calcitriol (0.5\u20131.0 \u00b5g) two or three times per week for 6 months. The changes of serum levels of calcium, phosphate, intact PTH, and FGF-23 were evaluated. <i>Results:<\/i> Baseline serum FGF-23 levels were markedly high. By intravenous calcitriol therapy, intact PTH levels decreased effectively in the first month (p < 0.001). In contrast, FGF-23 levels increased gradually during the study period (p = 0.027). The \u0394 serum FGF-23 level was significantly correlated with the total doses of calcitriol injected intravenously in 6 months in patients with refractory secondary hyperparathyroidism (R<sup>2 =<\/sup> 0.147; p = 0.036). <i>Conclusions:<\/i> Intravenous calcitriol decreased serum intact PTH level and increased serum FGF-23 levels significantly. Extremely high levels of serum FGF-23 in these patients may be attributed, at least in part, to the cumulative dose of vitamin D.<\/jats:p>","DOI":"10.1159\/000086347","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T10:58:36Z","timestamp":1118833116000},"page":"c94-c99","source":"Crossref","is-referenced-by-count":95,"title":["Intravenous Calcitriol Therapy Increases Serum Concentrations of Fibroblast Growth Factor-23 in Dialysis Patients with Secondary Hyperparathyroidism"],"prefix":"10.1159","volume":"101","author":[{"given":"Hiroshi","family":"Nishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Nii-Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeyoshi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Fujimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Fukagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI119809"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2F81664"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.2.497"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.2001.5084"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.101545198"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.00064.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa020881"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00328.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.2003.18.7.1227"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00604.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2004.04.029"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1359%2FJBMR.0301264"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200419081"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2003.12.102"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-021105"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00184.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2001.28113"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M408903200"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:11:09Z","timestamp":1745464269000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000086347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,15]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000086347","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,15]]}}}