{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:23:54Z","timestamp":1774448634680,"version":"3.50.1"},"reference-count":31,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; Nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (NC-CAH) is associated with hyperandrogenemia, chronic anovulation, hirsutism, acne and adrenal hyperplasia. A few studies have shown hyperinsulinemia and insulin insensitivity in NC-CAH. Hyperinsulinemia can stimulate leptin secretion, and androgens can inhibit leptin secretion. Thus, we designed a study to investigate the insulin levels and insulin sensitivity and the effect of chronic endogenous hyperinsulinemia and androgens on leptin in patients with NC-CAH. &lt;i&gt;Methods:&lt;\/i&gt; Eighteen women with untreated NC-CAH and 26 normally cycling control women with a similar body mass index (BMI) were studied. Basal hormones, fasted and fed insulin levels, leptin and stimulated 17-hydroxyprogesterone (17-OHP) concentrations were studied. Homeostasis model assessment was used to assess insulin sensitivity. &lt;i&gt;Results:&lt;\/i&gt; The basal 17-OHP, the free testosterone (fT) and dehydroepiandrosterone sulfate (DHEA-S) were significantly different in the 2 groups (p &lt; 0.05). Fasting and fed insulin levels of the NC-CAH group were higher than those of the control group (p &lt; 0.05) and insulin sensitivity was lower in NC-CAH than in controls (p &lt; 0.05). Insulin levels were correlated with fT and 17-OHP (p &lt; 0.05). Serum leptin levels for NC-CAH (25.9 \u00b1 12.5 \u00b5g\/l) did not differ from the controls (25.4 \u00b1 12.06 \u00b5g\/l) and were positively correlated with BMI (r = 0.725) and percent body fat (r = 0.710) for both groups (both p &lt; 0.001). Leptin levels were not correlated with estrogen or androgens, gonadotropins or insulin levels. &lt;i&gt;Conclusion:&lt;\/i&gt; Hyperinsulinemia and insulin insensitivity associated with hyperandrogenism were detected in untreated NC-CAH patients as in previous reports, whereas serum leptin levels did not differ from those of controls.<\/jats:p>","DOI":"10.1159\/000086363","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T10:58:36Z","timestamp":1118833116000},"page":"270-274","source":"Crossref","is-referenced-by-count":28,"title":["Hyperinsulinemia and Insulin Insensitivity in Women with Nonclassical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency: The Relationship between Serum Leptin Levels and Chronic Hyperinsulinemia"],"prefix":"10.1159","volume":"63","author":[{"given":"F.","family":"Sayg\u0131l\u0131","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Oge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2005,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.21.3.245"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1330383"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1990.tb03887.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.6.1692"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.6.1897"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-1376"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2004.02.127"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.75.6.1421"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2898%2900033-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.9.4472"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2F374470a0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.44.7.855"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.271.5.2365"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2F377527a0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00403921"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.45.10.1364"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.9.3243"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1999.0718"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.137.7.3144"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.12.4459"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.9.2849"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.5.2114"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.78.4.810"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00280883"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1370670"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-1001755"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-031737"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2004.02.052"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2003.10.056"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2003.08.024"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2802%2902995-3"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/86363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:11:15Z","timestamp":1745464275000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000086363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000086363","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}